ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ MỘT SỐ YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TYP 2 CÓ GAN NHIỄM MỠ KHÔNG DO RƯỢU (NAFLD)

Abstract

Aim: to describe the clinical, laboratory characteristics and associated factors with non-alcoholic fatty liver disease (NAFLD) in patients with diabetes mellitus type 2 (DM2). Subject and methods: a cross-sectional study among 70 patients with DM2 aged 18-70 in Endoscrinoloy Department & Endocrine consulting room – Bach Mai Hospital and satified the criteria of American Association for Liver Diseases (AASLD) 2018 about NAFLD. All participants underwent abdominal ultrasould and Fibroscan to measure liver stiffness (LSM) and liver steatosis (CAP). Results: 52,9% patients were female, the mean age was 51.3 ± 12.7. 71.4% patients were overweight/obese. In Fibroscan, 82.9% patients had liver steatosis, the prevalence of grade 1, 2, 3 were 24.3%, 11.4%, and 47.1%, respectively. BMI, waist-hip ratio, ALT and LSM were signigicantly higher in patients with liver steatosis grade 3 than grade 1-2 and normal ones. BMI, HbA1c, HDL-C and LSM were associated with CAP. Conclusion: High prevalance of patients with DM2 had liver steatotis in Fibroscan. CAP, an index for liver steatosis, was associated with BMI, HbA1c, HDL-C and LSM.