KHẢO SÁT NỒNG ĐỘ C – PEPTIDE VÀ MỐI LIÊN QUAN VỚI BIẾN CHỨNG VI MẠCH Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TYPE 2

Abstract

C–Peptide is a polypeptide secreted simultaneously and in equimolar amounts with insulin from pancreatic beta cells. By measuring fasting serum C – Peptide, we can evaluate endogenous insulin reserve in diabetic patients. Aims: To survey on fasting serum C – Peptide and to comment on the association between fasting serum C – Peptide and diabetic retinopathy and urine albumin. Subjects and methods: cross-sectional description study of 87 patients with a diagnosis of type 2 diabetes at Bach Mai Hospital from January 2021 to August 2021. Results: In this study, the mean value of fasting serum C – Peptide is 0,83 ± 0,35 nmol/l. Negative correlation was seen between fasting serum C – Peptide and urine albumin level (r=-0,352, p=0,001, spearman test).The mean values of fasting serum C–Peptide in patients with microalbuminuria and no microalbuminuriaare 0,72 ±  0,34 nmol/l  and 0,88 ± 0,35 nmol/l respectively. Also in this study, the mean values of fasting serum C – Peptide in patients with diabetic retinopathy and no diabetic retinopathy are 0,72 ± 0,33 nmol/l and 0,9 ± 0,36 nmol/l respectively. Conclusion: The mean value of fasting serum C – Peptide in this study is 0,83 ± 0,35 nmol/l. The current study showed a significant correlation between fasting serum C – Peptide and urine albumin level. Fasting serum C – Peptide was significantly associated with diabetic retinopathy and microalbuminuria.