Article Sidebar

pdf
Date Published: 26/11/2024
Abstract Views: 60
Views pdf: 43
DOI: https://doi.org/10.51298/vmj.v544i2.11842
Issue
Vol. 544 No. 2 (2024)
Section
Các bài báo
How to Cite
Hà, T. T. H., Phạm, H. H., & Đặng, Q. Ái. (2024). ANALYSIS OF BACTERIAL CULTURES IN PATIENTS WITH GASTROINTESTINAL INFECTIONS UNDERGOING SURGICAL INTERVENTION. Vietnam Medical Journal, 544(2). https://doi.org/10.51298/vmj.v544i2.11842

ANALYSIS OF BACTERIAL CULTURES IN PATIENTS WITH GASTROINTESTINAL INFECTIONS UNDERGOING SURGICAL INTERVENTION

Thị Thúy Hằng Hà, Hồng Hạnh Phạm, Quốc Ái Đặng

Main Article Content

Abstract

Background: This study focuses on gastrointestinal infections requiring surgical intervention, a common acute condition in surgical emergencies. The increasing antibiotic resistance of bacteria is leading to treatment failures, higher mortality risk, and prolonged hospital stays. Consequently, microbiological surveys are essential to guide antibiotic use based on clinical experience. Materials and Methods: The study was conducted through the analysis of medical records of patients with gastrointestinal infections requiring surgical intervention and bacterial identification cultures at the Department of General Surgery, Hanoi Medical University Hospital, from January 2023 to June 2024. Results: The predominant infection in the study was biliary tract infection, accounting for 87.53%. Specifically, Gram-negative bacteria producing extended-spectrum β-lactamases (ESBLs) were highly prevalent: Escherichia coli constituted 57.89% and Klebsiella spp. 28.33%. The main bacterial strains identified were Escherichia coli, Enterococcus spp., and Klebsiella. Escherichia coli exhibited high resistance rates to ampicillin/sulbactam (88.37%) and ciprofloxacin (75.57%). Klebsiella spp. showed high resistance rates to ampicillin/sulbactam (100%), ciprofloxacin (62.07%), and cefotaxime (57.89%). Conclusion: The prevalence of ESBL-producing Gram-negative bacteria in patients with gastrointestinal infections is alarming, with increasing antibiotic resistance to penicillins, third-generation cephalosporins, and quinolones.

Article Details

Keywords

gastrointestinal infections, antibiotic resistance, ESBL, Escherichia coli, Klebsiella spp., Enterococcus spp.

References

1. Fredric MP, Philip SB. (2007). “Intra-abdominal infections”, Current Opinion in Critical Care, 13:440–449.
2. Pieracci FM, Barie PS. (2007). “Management of severe sepsis of abdominal origin”Scand J Surg, 96(3):184-96.
3. Mulier S, Penninckx F, Verwaest C. (2003). “Factors Affecting Mortality in Generalized Postoperative Peritonitis: Multivariate Analysis in 96 Patients”, World J Surg, 27(4):379-84.
4. Rimola A, García-Tsao G, Navasa M. et al (2000). “Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document”, Journal of Hepatology, 32:142-153.
5. Nguyễn Văn Kính (2010). ”Phân tích thực trạng: Sử dụng kháng sinh và kháng kháng sinh ở Việt Nam”, nghiên cứu quốc gia Việt Nam GARP.
6. Hà Thị Thúy Hằng, Đặng Quốc Ái (2015). “Thực trạng sử dụng kháng sinh trong điều trị nhiễm khuẩn ổ bụng tại khoa Ngoại Bệnh viện Đại học Y Hà Nội”, tạp chí Y học thực hành
7. Mazuski JE, Tessier JM, May AK, et al (2017). “The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection”. Surg Infect (Larchmt); 18:1.
8. McHutchison JG, Runyon BA (1995). “Spontaneous bacterial peritonitis. In: Gastrointestinal and Hepatic Infections”, Surawicz CM, Owen RL (Eds), WB Saunders, Philadelphia. p.455.
9. Phạm Hùng Vân (2011). “Vi khuẩn Gram âm đề kháng kháng sinh thực trạng tại Việt Nam và các điểm mới về chuẩn mực biện luận đề kháng”, tạp chí y học Hồ Chí Minh , tr.138-148.