HỘI CHỨNG BÀN TAY BÀN CHÂN VÀ MỘT SỐ TÁC DỤNG KHÔNG MONG MUỐN CỦA CAPECITABINE TRÊN BỆNH NHÂN UNG THƯ TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI

Abstract

Objective: This study aims to assess the incidence and characteristics of hand-foot syndrome and other adverse effects of capecitabine in cancer patients at Hanoi Medical University Hospital, as well as to identify factors influencing these effects. Methods: A cross-sectional study was conducted from October 2017 to September 2019 in the hospital’s Oncology Department. We monitored 49 patients on capecitabine monotherapy, recording adverse effects and analyzing physiological, pathological, and laboratory data. Results: Hand-foot syndrome occurred in 51.02% of patients. Other adverse effects included vomiting (10.20%), nausea (12.24%), gastritis (2.04%), diarrhea (12.24%), and gastroesophageal reflux (6.12%). Severity of hand-foot syndrome was Grade 3 in 8.16% of patients, Grade 2 in 16.33%, and Grade 1 in 26.53%. Incidence was significantly higher in patients over 60 years (p=0.032), but severity was not age-dependent (p=0.184). Drug dosage and laboratory indices showed no significant correlation with adverse effects. Conclusion: Our study reveals a higher incidence of hand-foot syndrome and lower gastrointestinal adverse effects compared to international studies. Age influences the incidence of hand-foot syndrome, while drug dosage and laboratory indices do not significantly affect adverse effects. Further pharmacogenomic research is needed to improve management strategies.