ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ TÍNH NHẠY CẢM KHÁNG SINH CỦA AEROMONAS HYDROPHILA GÂY NHIỄM KHUẨN HUYẾT TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG

Abstract

Objectif: To describe the clinical, paraclinical characteristics and antibiotic susceptibility of Aeromonas hydrophila causing septicemia at the National Hospital of Tropical Diseases. Methods: Cross-sectional, retrospective study of all patients diagnosed with septicemia caused by Aeromonas hydrophila during period 2018 to 2024. Result: 37 patients were enrolled in the study, 27 of which was males (73%), cirrhosis was the underlying disease with the highest rate (67.5%). Clinical manifestations were diverse: 43.2% had skin and soft tissue infections, mainly blisters with bleeding on the lower legs; 83.7% had organ failure, of which most had failure of more than 2 organs (64.8%). The rate of septic shock was 35.1%, the overall fatality rate was 29.7%. Over 90% of isolated bacterial strains were sensitive to ceftriaxone, cefepime, ciprofloxacin and carbapenem groups. The sensitivity rate to ceftazidime, amikacin and levofloxacin was just over 80%. Aeromonas hydrophila were resistant to ampicillin (80.6%), ampicillin/sulbactam (40.6%), and piperacillin/tazobactam (18.9%). Conclusion: A. hydrophila septicemia is uncommon, but can cause notable rates of morbidity and mortality. It is important to have a suspicion of A. hydrophila infection in cirrhosis patients with fever and blisters with bleeding on the lower legs at initial presentation. Prompt diagnosis and early treatment with effective antibiotics are vital.