ROLE OF MAGNETIC RESONANCE IMAGING FOR DISTINGUISHING OVARIAN CLEAR CELL CARCINOMA FROM HIGH-GRADE SEROUS CARCINOMA
Main Article Content
Abstract
Objectives: the study aimed to evaluate the value of magnetic resonance imaging (MRI) for distinguishing ovarian clear cell carcinoma (CCC) from high–grade serous carcinoma (HGSC). Methods: we analyzed MRI data of 34 tumors in 30 patients with CCC, were compared with those of 49 tumors in 32 patients with HGSC, comfirmed by surgery and pathology. MRI features included: laterality, shape, size, configuration, papillary projection, signal intensity, enhancement, peritoneal implant, lymphadenopathy, ascites. Results: there was a statistically significant difference in the mean maximum diameter, laterality (p < 0.001 and p = 0.001, respectively) between CCC and HGSC. Compared to HGSCs, CCCs were more frequently oval (26/34, 76.5% vs 9/49, 18.4%; p < 0.001), more often cystic (19/34, 55.9% vs 7/49, 14.3%; p < 0.001) and unilocular (20/26, 76.9% vs 5/23, 21.7%; p <0.001), had T1-hyperintense cystic components more often (16/26, 61.5% vs 4/23, 17.4%; p = 0.002), had larger papillary projections (53.3 ± 19.5mm vs 23.8 ± 12mm; p < 0.001), were peritoneally implanted less frequently (p = 0.09) and had fewer ascites (p < 0.001). Conclusion: CCC typically showed an oval, unilocular cystic mass with large papillary projection and T1-hyperintense cystic components. MRI could be helpful for distinguishing CCC from HGSC.
Article Details
Keywords
ovary, clear cell carcinoma, high-grade serous carcinoma, magnetic resonance imaging.
References
2. Ma FH, Qiang JW, Zhang GF, Li HM, Cai SQ, Rao YM. Magnetic resonance imaging for distinguishing ovarian clear cell carcinoma from high-grade serous carcinoma. J Ovarian Res. 2016;9(1):40. doi:10.1186/s13048-016-0251-x
3. Lee YY, Kim TJ, Kim MJ, et al. Prognosis of ovarian clear cell carcinoma compared to other histological subtypes: A meta-analysis. Gynecol Oncol. 2011;122(3): 541-547. doi:10.1016/ j.ygyno.2011.05.009
4. Penson RT, Dizon DS, Birrer MJ. Clear cell cancer of the ovary. Curr Opin Oncol. 2013; 25(5): 553-557. doi:10.1097/ CCO.0b013e328363e0c7
5. Glasspool RM, McNeish IA. Clear Cell Carcinoma of Ovary and Uterus. Curr Oncol Rep. 2013; 15(6): 566-572. doi:10.1007/s11912-013-0346-0
6. Min KW, Park MH, Hong SR, et al. Clear Cell Carcinomas of the Ovary: A Multi-Institutional Study of 129 Cases in Korea With Prognostic Significance of Emi1 and Galectin-3. Int J Gynecol Pathol. 2013;32(1): 3-14. doi:10.1097/PGP. 0b013e31825554e9
7. Hassen K, Ghossain MA, Rousset P, et al. Characterization of Papillary Projections in Benign Versus Borderline and Malignant Ovarian Masses on Conventional and Color Doppler Ultrasound. Am J Roentgenol. 2011;196(6):1444-1449. doi: 10.2214/AJR.10.5014
8. Choi HJ, Lee JH, Seok Lee J, et al. CT Findings of Clear Cell Carcinoma of the Ovary. J Comput Assist Tomogr. 2006;30(6):875-879. doi:10.1097/ 01.rct.0000220795.45782.1d