PATIENT CHARACTERISTICS OF HEMOPHILIA WITH HEMATURIA AT CHILDREN'S HOSPITAL 1
Main Article Content
Abstract
Background: Hemophilia is a rare congenital bleeding disorder characterized by a deficiency in blood clotting factors. Hematuria is a common symptom in children with hemophilia, occurring in 28% to 45% of cases. Objectives: Determine the rate of hematuria in hospitalized hemophilia patients and describe the epidemiological, clinical, and laboratory features of hematuria in hemophilia patients. Materials and methods: A cross-sectional description of 98 hemophilia patients admitted to the Dengue Fever-Hematology Department at Children's Hospital 1 from January 1, 2022, to July 31, 2023. Results: The rate of hematuria was 22.4% (macroscopic hematuria accounting for 73%) and on average, for every age increase, the odds of hematuria increased by 30%. The rate of increased blood pressure was higher in the hematuria group compared to the non-hematuria group. Most hemophilia patients with hematuria did not have an identifiable cause. No cases of decreased eGFR or decreased blood albumin were observed and blood albumin was lower in the macroscopic hematuria group compared to the microscopic group. The most common abnormal feature of imaging in hemophilia patients with hematuria was renal pelvis dilation. The positive urine protein rate was 13.3% and 90% of urine samples had a red blood cell (RBC) deformation rate > 30%, with echinocytes being the most common type of deformed RBC. Conclusions: Many hemophilia patients with hematuria exhibited abnormalities in blood pressure, blood biochemistry, urine tests, and renal-urinary imaging. Therefore, further studies with a larger sample size and longer follow-ups are needed to monitor the outcomes in these patients.
Article Details
Keywords
Hemophilia, hematuria, Children's Hospital 1
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