MỐI LIÊN QUAN GIỮA ACID URIC HUYẾT THANH VỚI TĂNG HUYẾT ÁP, BỆNH THẬN MẠN, VÀ HỘI CHỨNG CHUYỂN HÓA Ở NGƯỜI BỆNH ĐÁI THÁO ĐƯỜNG TÍP 2

Abstract

Background: Studies have shown an association between hyperuricemia, type 2 diabetes, and metabolic syndrome (MetS). Besides, increased uric acid is also associated with the progression of chronic kidney disease (CKD), hypertension, and MetS. A few recent reports have evaluated the relationship between uric acid and hypertension, chronic kidney disease, or MetS syndrome, but they are unclear. Method: Cross-sectional study, collecting data on serum uric acid and comorbidities such as hypertension, MetS, and CKD in type 2 diabetic patients who have been treated at Le Van Thinh Hospital. Results: A total of 156 patients with type 2 diabetes, aged 18 years and older, participated in this study. The mean age of participants was 64.9±12.3; 52.6% of whom were males. The average serum uric acid level was 6.5 mg/dL, and the rate of hyperuricemia was 43%. In the hyperuricemia group, there were a higher number of accompanying diseases. Uric acid was positively correlated with blood glucose in the chronic kidney disease group (r = 0.4, p = 0.02), with serum creatinine and urea levels in the hypertension group (r = 0.26, p = 0.004, and r = 0.32, p = 0.009), and in the MetS group (r = 0.42, p = 0.001). Conclusion: Hyperuricemia in patients with type 2 diabetes is associated with increased rates of hypertension, chronic kidney disease, and metabolic syndrome.