ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ THOÁI HÓA KHỚP GỐI NGUYÊN PHÁT BẰNG COLLAGEN THỦY PHÂN TRỌNG LƯỢNG PHÂN TỬ THẤP TIÊM NỘI KHỚP

Abstract

Objectives: 1. To evaluate the results of treatment of primary knee osteoarthritis with intra-articular injection of low molecular weight hydrolyzed collagen. 2. To review the adverse effects of the above therapy. Subjects and methods: The study was conducted on 58 patients diagnosed with stage 2-3 primary knee osteoarthritis according to Kellgren and Lawrence, divided into 2 groups: Group 1 included 23 patients injected with Arthrys and Group 2 included 35 patients injected with Synolis, treated as outpatients at Hanoi Medical University Hospital from August 2023 to July 2024. Prospective, interventional, longitudinal follow-up study with comparison between the 2 groups. Results: After 12 weeks of treatment: in the Arthrys injection group, the average VAS score was from 6.02 at the pre-study time (T0), clearly decreased from week 1 to 4.52, the rate of 30% improvement in VAS score was 21.74% and continued to improve until week 12, the VAS score was 1.61, the rate of 30% improvement in VAS score was 82.61%; the overall WOMAC score was from 35.26±3.54 (T0), clearly improved from week 4 to 21.09, the rate of 50% improvement in WOMAC score was 43.48%; continued to decrease in week 8 and by week 12 to 12.88±2.11, the rate of 50% improvement in WOMAC score was 78.26%; LEQUESNE score from 11.32 at T0, decreased significantly from week 4 and decreased to 2.44 at T12. The difference in improvement of VAS, WOMAC, LEQUESNE scores between the Arthrys and Synolis groups was not statistically significant (p>0.05). The rate of adverse effects of Arthrys injection therapy was 12.9%, including 2 cases of post-injection tension, 1 case of prolonged pain 24 hours after injection and knee effusion but decreased rapidly when using NSAIDs. 91.3% of patients were satisfied and very satisfied with this treatment method. Conclusion: Low molecular weight collagen intra-articular injection therapy for primary knee osteoarthritis has the effect of reducing pain from the 1st week, improving knee joint function clearly from the 4th week and lasting until the 12th week through reducing VAS, WOMAC, LEQUESNE scores (p<0.05).