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Date Published: 16/12/2024
Abstract Views: 23
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DOI: https://doi.org/10.51298/vmj.v545i1.12200
Issue
Vol. 545 No. 1 (2024)
Section
Các bài báo
How to Cite
Nguyễn, T. S., Mai, T. H., Hồ, K. D., Vương, T. B. T., Ngô, T. H., Trần, T. T. C., Phạm, T. V., Vương, T. H., Phạm, T. T. H., & Nguyễn, N. D. (2024). REPORT OF TWO CASES OF ABNORMAL PREGNANCIES DUE TO CONFINED PLACENTAL MOSAICISM OF TRISOMY 16. Vietnam Medical Journal, 545(1). https://doi.org/10.51298/vmj.v545i1.12200

REPORT OF TWO CASES OF ABNORMAL PREGNANCIES DUE TO CONFINED PLACENTAL MOSAICISM OF TRISOMY 16

Thị Sim Nguyễn, Trọng Hưng Mai, Khánh Dung Hồ, Thị Bích Thủy Vương, Thị Hương Ngô, Thị Thu Cảnh Trần, Thế Vương Phạm, Tiến Hòa Vương, Thị Thanh Hiền Phạm, Ngọc Dũng Nguyễn

Main Article Content

Abstract

From conception to delivery, the placenta plays a crucial intermediary role between the mother and the fetus. Numerous studies have highlighted the association between intrauterine growth restriction (IUGR) and placental chromosomal abnormalities, particularly confined placental mosaicism (CPM) of Trisomy 16. We report two cases of IUGR with non-invasive prenatal screening (NIPS) results suggestive of chromosomal abnormality 16, in which CPM of Trisomy 16 was subsequently confirmed. One pregnancy resulted in a live birth, while the other ended in an intrauterine fetal demise. Based on these cases, we recommend prenatal screening for chromosomal abnormality 16 to enable early detection and prognostication of placental abnormalities leading to IUGR

Article Details

Keywords

Confined placental mosaicism (CPM); intrauterine growth restriction (IUGR); Trisomy 16; non-invasive prenatal screening (NIPS); prenatal diagnosis; genetic counseling.

References

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