ĐIỀU TRỊ LỌC MÁU HẤP PHỤ TRONG NGỘ ĐỘC CẤP DIQUAT

Abstract

Objective: To evaluate the effectiveness of hemoperfusion in patients with acute diquat poisoning. Method: A prospective study included 34 patients with acute diquat poisoning treated by hemoperfusion at the Poison Control Center of Bach Mai Hospital. Results: On admission, the median of blood diquat concentration was 8.09 (3.05-28.8) mcg/ml. The time from ingestion to hemoperfusion was 10.1 ± 5.6 hours. With hemoperfusion treatment, the overall survival rate was 38.3%. The in-hospital mortality rate was 55.9%, the 28-day mortality rate was 61.8%, and the rate of neurological sequelae was 2.94%. Hemoperfusion significantly reduced blood diquat concentration: 87.7% reduction after the first hemoperfusion (from 8.1 to 1.7 µg/ml); diquat was negative in the blood after about 7.5 hours; diquat was not detected in the blood in most of the patients after 3 hemoperfusions. Common complication of hemoperfusion was thrombocytopenia, the largest reduction was 13.5% after the first filtration. Catheter bleeding occurred in one patient. Conclusion: Hemoperfusion significantly eliminated diquat, reducing hospital mortality of diquat poisoning. The complications of hemoperfusion were common mild, with the most common was thrombocytopenia.