KẾT QUẢ ĐIỀU TRỊ BỆNH NHÂN LAO PHỔI SỬ DỤNG MỘT SỐ PHÁC ĐỒ CÁ THỂ TẠI BỆNH VIỆN PHỔI THÁI NGUYÊN

Abstract

Introductions: Individualized treatment regimen for pulmonary tuberculosis patients who cannot tolerate standard regimens is necessary. Objectives: Describe the results of treating pulmonary tuberculosis patients with individual regimens and some factors affecting treatment results. Methods: descriptive method. Subjects patients treated with individual regimens from 6/2023 to 12/2024. Sample size: select all patients treated with regimens 2SRHZE/4RHE; 2SHZE/4HE; 2RZE/6RE; 9RELfx, 30 patients. Results: Male patients 86.7%, over 60 years old accounted for 40%. Through treatment, the symptoms of cough, chest pain, mild fever in the afternoon and rales in the lungs when admitted to the hospital were 100%, 86.7%, 80% and 100% respectively. After 2 months, cough and rales in the lungs were 60%, 6.7%, 3.3% and 33.3%. After 6 months, only cough and rales in the lungs were 6.7%. The sputum staining when admitted to the hospital, after 2 months and after 6 months of treatment were: AFB positive: 56.7%, 10%, 6.7%. AFB negative: 43.3%, 90%, 93.3%. The hematological and biochemical blood values ​​of the patients when admitted to the hospital, after 2 months and after 6 months were respectively: increased white blood cells: 56.7%, 6.7% and 3.3%; Hb reduction: 36.7%, 20% and 16.7%; SGOT value increase: 13.3%, 26.7% and 10%; SGPT value increase: 13.3%, 16.7% and 6.7%; uric acid increase: 10%, 33.3% and 13.3%; urea increase: 3.3%, 6.7% and 3.3%; Treatment results have a cure rate of 86.7%, treatment completion rate of 6.7%, failure rate of 6.7%. Discussions: Individualized regimens are the personalization of treatment regimens to optimize effectiveness and minimize side effects for each specific patient. Individualized regimens help keeping enhance the quality of life for patients. Conclusions: Individualized regimens 2SRHZE/4RHE; 2SHZE/4HE; 2RZE/6RE; 9RELfx tuberculosis treatment helps improve clinical symptoms and laboratory tests significantly for patients.