ĐẶC ĐIỂM ĐA HÌNH RS676210 GEN APOB Ở BỆNH NHÂN RỐI LOẠN LIPID MÁU

Abstract

Introduction: Several studies have shown that the rs676210 polymorphism of the APOB gene is associated with changes in blood lipid component levels and the risk of cardiovascular diseases. Objective: To identify the characteristics of the rs676210 polymorphism in the APOB gene and its association with blood lipid component levels. Materials and methods: A cross-sectional descriptive study with analysis was conducted on 49 dyslipidemic patients who visited Can Tho University of Medicine and Pharmacy Hospital from October 2023 to October 2024. Results: The average age was 53.57 ± 11.07 years, with a female-to-male ratio of 1.33. The smoking rate was 20.4%, and the average BMI was 23.8 ± 2.45 kg/m². The prevalence of hypertension and diabetes was 28.6% and 16.3%, respectively. The mean total cholesterol level was 6.85 ± 1.11 mmol/L, HDL-c was 1.34 ± 0.31 mmol/L, LDL-c was 4.43 ± 0.76 mmol/L, and triglycerides were 2.55 ± 1.40 mmol/L. The genotype distribution of the rs676210 polymorphism in the APOB gene was as follows: AA 42.9%, GA 46.4%, and GG 10%. The allele frequencies were 66.1% for allele A and 33.9% for allele G. Triglyceride levels tended to be higher in the GA genotype than in AA and GG, at 3.14 ± 1.56, 2.13 ± 1.23, and 1.33 ± 0.15 mmol/L, respectively; this difference was statistically significant (p = 0.015). No statistically significant associations were observed between genotype and total cholesterol, LDL-c, or HDL-c levels (p > 0.05). Conclusion: The A allele was commonly distributed among dyslipidemic patients, and the GA genotype was associated with elevated triglyceride levels