ĐẶC ĐIỂM LÂM SÀNG BỆNH XƠ CỨNG BÌ HỆ THỐNG TẠI BỆNH VIỆN DA LIỄU TRUNG ƯƠNG

Abstract

Systemic sclerosis (SSC) is the second most common autoimmune disease after systemic lupus erythematosus. This retrospective and prospective cross-sectional study was conducted on 81 SSC patients to describe some clinical characteristics of the disease at the National Hospital of Dermatology and Venereology. The results showed that the proportion of female patients was 75.3%, the average age was 49.81 ± 12.22 years. SSC with diffuse skin lesions accounted for 66.7%, and limited skin lesions accounted for 33.3%. Skin lesions included swelling of the hands and fingers (54.3%), difficulty opening the mouth (49.4%), cutaneous pigmentation disorders (49.4%), short frenulum (14.8%) and subcutaneous calcification (4.9%). The most severe skin thickening was on the fingers with mRSS score of 3.56 ± 1.21 points, 2.84 ± 1.46 points for the hands, and the least thickened skin was on the thighs and abdomen. 65.4% of patients had mRSS score above 14 points. Extremity lesions included Raynaud's phenomenon (90.1%), pitting scars on the fingertips (63%), ulcers on the fingertips (18.5%), necrosis on the fingertips (13.6%), and telangiectasia (39.5%). Symptoms of pitting scars, of the respiratory and cardiovascular systems were more common in the diffuse form than in the limited form, the difference was significant with p<0.05.