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CLINICAL STUDY ON CORNEAL ENDOTHELIAL CHANGES AFTER PHACOEMULSIFICATION IN EYES WITH A PRIOR ACUTE ANGLE-CLOSURE ATTACK
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Abstract
Objective: To investigate changes in corneal endothelial cell density and morphology following phacoemulsification surgery for patients with acute angle closure. Subjects and Methods: A longitudinal descriptive study conducted on 35 patients diagnosed with acute angle closure and cataracts, who were indicated for phacoemulsification surgery at the Glaucoma Department of Eye Hospital of Ho Chi Minh City from December 2023 to June 2024. Patients underwent preoperative and postoperative corneal endothelial cell imaging using the NIDEK CEM 530, with assessments at 1 month postoperatively. Phacoemulsification time, cumulative dissipated energy (CDE), and total ultrasound energy were recorded after the surgery. Results: The mean age of the study population was 58.9 ± 7.3 years, with the condition predominantly affecting female patients. Visual acuity and intraocular pressure (IOP) showed statistically significant improvements 1 month after surgery. Besides, there was a statistically significant decrease in endothelial cell density, cell variability, and central corneal thickness at 1 month postoperatively. A positive correlation was observed between phacoemulsification time, total ultrasound energy, cumulative dissipated energy, and the rate of endothelial cell loss 1 month after surgery. Conclusion: Acute angle closure is a common condition in the elderly, particularly among Asian populations and women. Phacoemulsification surgery is currently a safe and effective method to lower intraocular pressure and improve visual acuity while preventing disease progression to angle-closure glaucoma. At 1-month post-surgery, there was a statistically significant decrease in corneal endothelial cell density, which positively correlated with phacoemulsification time, cumulative dissipated energy, and total ultrasound energy.
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Keywords
Acute angle closure, phacoemulsification surgery, corneal endothelial cells
References
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