Article Sidebar

pdf
Date Published: 23/06/2025
Abstract Views: 123
Views pdf: 60
DOI: https://doi.org/10.51298/vmj.v551i1.14514
Issue
Vol. 551 No. 1 (2025)
Section
Các bài báo
How to Cite
Ngô Trần Phước, N., Trần Viết, A., Phạm Thị Ngọc, N., & Bùi Thế, D. (2025). POLYMORPHISM RS2383206 OF THE CDKN2B-AS1 GENE IN PATIENTS WITH CHRONIC CORONARY SYNDROME AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL. Vietnam Medical Journal, 551(1). https://doi.org/10.51298/vmj.v551i1.14514

POLYMORPHISM RS2383206 OF THE CDKN2B-AS1 GENE IN PATIENTS WITH CHRONIC CORONARY SYNDROME AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

Nguyên Ngô Trần Phước, An Trần Viết, Nga Phạm Thị Ngọc, Dũng Bùi Thế

Main Article Content

Abstract

Background: Chronic coronary syndrome is a chronic disease with a pathogenesis influenced by various factors, including genetic factors. Several studies have shown an association between the rs2383206 polymorphism of the CDKN2B-AS1 gene and the severity of coronary artery lesions. Objectives: To investigate the characteristics of the rs2383206 polymorphism of the CDKN2B-AS1 gene in relation to the severity of coronary artery lesions in patients with chronic coronary syndrome who underwent coronary angiography at the Interventional Cardiology-Neurology Department of Can Tho University of Medicine and Pharmacy Hospital. Study Subjects and Methods: A cross-sectional descriptive study with analysis was conducted on 43 patients with chronic coronary syndrome who underwent coronary angiography at the Interventional Cardiology-Neurology Department of Can Tho University of Medicine and Pharmacy Hospital from June 2023 to December 2024. Results: The average age of the study population was 67,19 ± 9,6 years, with a predominantly male gender distribution. The prevalence of overweight-obesity (BMI ≥ 23 kg/m²) was 60,5%. Among cardiovascular risk factors, hypertension (93,0%) and dyslipidemia (83,7%) were the most common. The genotype frequencies of the rs2383206 polymorphism were 39,5% for GG, 60,5% for GA, and 0% for AA. The prevalence of the G allele was 60,7%, and the A allele was 20,3%. A statistically significant association was observed between the GA genotype and an increased prevalence of type 2 diabetes mellitus (OR= 1,803, 95% confidence interval: 1,047-3,104, p= 0,021). However, no statistically significant difference was found between the frequencies of the GG, GA, and AA genotypes and the severity of coronary artery lesions. Conclusions: In the study of the rs2383206 polymorphism of the CDKN2B-AS1 gene in 43 patients with chronic coronary syndrome who underwent coronary angiography at the Interventional Cardiology-Neurology Department of Can Tho University of Medicine and Pharmacy Hospital, the GG genotype and the G allele were observed to be the most prevalent. A larger sample size study is needed to investigate the association between polymorphism frequencies and the severity of coronary artery stenosis.

Article Details

Keywords

CDKN2B-AS1, rs2383206, chronic coronary syndrome, coronary artery lesion

References

1. Roth, G. A., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., et al. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159). 2018;1736-1788.
2. Jing, J., Su, L., Zeng, Y., Tang, X., Wei, J., Wang, L., & Zhou, L. Variants in 9p21 predicts severity of coronary artery disease in a Chinese Han population. Annals of Human Genetics, 80(5). 2016; 274-281.
3. Kumar, J., Yumnam, S., Basu, T., et al. Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS. Clinical Genetics, 79(6). 2010; 588-593.
4. Wójcik-Odyniec, J., Odyniec, A., Cieplucha, E., Szymańska-Garbacz, E., Saryusz-Wolska, M., Borkowska, A., Borowiec, M., Czupryniak, L., & Loba, J. Time of onset of coronary artery disease in diabetic patients depends on genetic polymorphism in region 9p21 but not in 1p25. Clinical Diabetology, 5(1). 2016; 7-14.
5. Huang, K., Zhong, J., Li, Q., Zhang, W., Chen, Z., Zhou, Y., Wu, M., Zhong, Z., Lu, S., & Zhang, S. Effects of CDKN2B‐AS1 polymorphisms on the susceptibility to coronary heart disease. Molecular genetics & genomic medicine, 7(11). 2019; e955.
6. Bogari, N. M., Allam, R. M., Dannoun, A., Athar, M., Bouazzaoui, A., Elkhateeb, O., Porqueddu, M., Amer, S. A., Elsayed, A., & Colombo, G. I. Role of single nucleotide polymorphism rs2383206 on coronary artery disease risk among Saudi Population: a case-control study. European Review for Medical & Pharmacological Sciences. 2023; 27(14).
7. Sayols-Baixeras, S., Lluís-Ganella, C., Lucas, G., & Elosua, R. Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants. The application of clinical genetics. 2014; 15-32.
8. Wu, Y., Zhang, C., Li, Y., et al. Genetic polymorphism of 9p21 rs2383206 is associated with coronary artery disease and its severity in a Chinese population. Journal of Clinical Laboratory Analysis, 32(3). 2018; e22323.