ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ ĐIỀU TRỊ BỆNH NHÂN UNG THƯ VÚ GIAI ĐOẠN SỚM THỂ MÔ BỆNH HỌC THUẬN LỢI TẠI BỆNH VIỆN K

Abstract

We aimed to assess clinical, paraclinical characteristics and treatment of favourable histologic types in early stage breast cancer at Vietnam National Cancer Hospital. Materials and Method: Retrospective study on medical records of 30 cases diagnosed at early breast cancer from 2019 to 2025 in Vietnam National Cancer Hospital, pathological diagnosis are mucinous carcinoma, cribriform carcinoma or tubular carcinoma. Results: The most common syndrome was palpable breast mass by self-breast examination. There were 30 cases including: 43.3% of mucinous carcinoma, 33.3% of cribriform carcinoma and 23.4% of tubular carcinoma. Patients’ mean age was 56.3 (range: 38-82 years old). The most common syndrome was palpable breast mass by self-breast examination (70%). The mean diameter of tumors was 3.0 cm (from 0.4 to 15). Tumors were mostly located in the right breast (66.7%) and the upper outer quadrant (46.7%). The percentage of disease stage I, II and III were 56.7%, 30% and 13.3% respectively. The positive lymph node proportion at diagnosis was only 13.3%. The immunohistochemistry testing showed that the most cases were positive hormone receptors (96.7%), negative HER2 (3.3%) and low Ki67 (96.7%). Surgery was the mainstay treatment (100%), 16.7% of cases were given chemotherapy, 96.7% of cases treated endocrine therapy and 30% having radiation. Conclusion: Favourable histologic types are uncommon in breast carcinoma. The most common subtype is mucinous carcinoma. The mean age of patients at diagnosis is relatively high. There are many good prognostic factors including high mean age, early stage, less node involvement, positive hormone receptors, negative HER2 and low Ki67. Surgery is the main treatment, chemotherapy is less likely to be administered.