FORECASTING THE RISK OF FRACTURE ACCORDING TO THE FRAX MODEL AND SOME RELATED FACTORS IN PATIENTS WITH CHRONIC KIDNEY DISEASE UNTREATED TO REPLACE KIDNEYS AT THAI BINH GENERAL HOSPITAL

Thủy Trần Xuân, Hùng Vũ Phi, Anh Bùi Thị Lan

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Abstract

Objectives: Forecasting the risk of fracture according to the Frax model and some related factors in patients with chronic kidney disease untreated to replace kidneys at Thai Binh General Hospital. Subjects and methods: The study described cross -sectional conducted on 84 patients with chronic kidney disease has not been treated for kidney replacement at the Department of Nephrology- Musculoskeletal Osteoarthritis Hospital of Thai Binh Province. Results: The average age research object is 66 ± 12.7 years old. The risk factors for osteoporosis according to the FRAX model: a history of fractures accounts for 6.0%, the use of prolonged corticosteroids accounts for 7.1%, drinking alcohol accounts for 17.9%. The probability of hip fractures after 10 years according to the FRAX model in BTM patient is 2.13 ± 1.33. The minimum probability of hip fractures is 0.1% (phases on IV and V). The maximum probability of hip fractures is 5.8% (phase IIIB). The risk of an average main fracture in 10 years (FRAX) according to bone density in the osteoporosis group (12.14 ± 7.48 %) is higher than the osteoporosis group. The risk of an average hip fracture for 10 years (frax) according to bone density in the osteoporosis group (2.81 ± 1.51%) is higher than that of non -osteoporosis. 8.3% of the risk of main fractures is high and 91.7 % have low risk of fractures. There are 22.6% of the risk of high hip fractures and 77.4% are at a low risk of hip fractures. Age, total calcium concentration and glomerular filtration level are factors that affect the risk of hip bone broken in patients with chronic kidney disease.

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References

1. Bikbov B, et al. (2020), “Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017”, The Lancet, 395(10225): p.709-733.
2. Organization W.H. (1998), “Guidelines for preclinical evaluation and clinical trials in osteoporosis”, World Health Organization, Geneva.
3. Fang Y, et al. (2014), “Early chronic kidney disease–mineral bone disorder stimulates vascular calcification”,Kidney International,85(1):p.142-150.
4. Nguyễn Minh Thủy (2010), “Nghiên cứu mật độ xương ở bệnh nhân suy thận mạn từ 50 tuổi trở lên và một số yếu tố liên quan”, Luận văn thạc sĩ Y học, Trường Đại học Y Hà Nội, Hà Nội.
5. Nguyễn Văn Thanh (2009), “Nghiên cứu mật độ xương và một số yếu tố liên quan ở bệnh nhân suy thận mạn chưa điều trị thay thế”, Luận văn tốt nghiệp bác sĩ nội trú, Đại học Y Hà Nội, Hà Nội.
6. Thái Văn Chương (2013), “Dự báo xác suất nguy cơ gãy xương sau 10 năm theo mô hình frax ở nam giới Việt Nam từ 60 tuổi trở lên”, Luận văn thạc sĩ Y học, Trường Đại học Y Hà Nội, Hà Nội.
7. Lin H.-H, Huang C.-Y, Hwang L.-C. (2018), “Association between metabolic syndrome and osteoporosis in Taiwanese middle-aged and elderly participants”, Archives of Osteoporosis, 13: p. 1-7.