EVALUATION THE CORRELATION OF THE APE, AFP-L3, PIVKA-II WITH CLINICAL AND SUBCLINICAL FACTORS OF HEPATITIS C PATIENTS

Phạm Cẩm Phương1,, Phạm Văn Thái1, Nguyễn Thuận Lợi1, Nguyễn Văn Dũng2, Lê Thị Hồng Linh2, Võ Thị Thúy Quỳnh1, Lê Thị Bích Ngọc1, Vũ Bình Thư1, Vũ Thị Thu Hiền1, et al.1,2
1 Nuclear Medicine and Oncology Center, Bach Mai Hospital
2 Department of Infectious Diseases, Bach Mai Hospital

Main Article Content

Abstract

Aims: To describe some clinical and subclinical characteristics of hepatitis C patients; evaluated the correlation of AFP, AFP - L3 and PIVKA-II with the characteristics of hepatitis C patients. Patients and methods: A prospective descriptive study on 33 hepatitis C patients. Results: Male patients accounted for the majority, the male/female ratio was 2/1, the average age of both men and women was 53.7 years old. Among hepatitis C patients, alcoholism was the highest rate of 39.4%. Common clinical symptoms were anorexia, fatigue, and abdominal distension. Indicators higher than normal values ​​were AST 173.5 ± 449 U/L, ALT 121.8 ± 258.4 U/L. In the group of patients with tumor, one of the three markers AFP, AFP-L3, PIVKA-II exceeded the threshold rate was 87.5%, in the group of patients without tumor, all three indexes below the threshold was 22.2%. Conclusions: AFP, AFP-L3and PIVKA-II values ​​were elevated in the majority of hepatitis C patients with tumors.

Article Details

References

1. The Washington manual of medical therapeutics 33nd edition. Hyuna Sung PhD Jacques Ferlay MSc, M.R.L.S.M.M.L.M.I.S.M., et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. ƯHO
2. Lefkowitch, J.H. (2007). Liver Biopsy Assessment in Chronic Hepatitis. Archives of Medical Research. 38(6), 634-643.
3. Rockey, D.C., Caldwell S.H., Goodman Z.D., et al. (2009). Liver biopsy. Hepatology. 49(3), 1017-44
4. Ricco G et al. (2018). Impact of etiology of chronic liver disease on hepatocellular carcinoma biomarkers. Cancer Biomark; 21(3):603-612
5. Lim T.S., D.Y. Kim, K.-H. Han, et al (2016). Combined use of AFP, PIVKA-II, and AFP-L3 as tumor markers enhances diagnostic accuracy for hepatocellular carcinoma in cirrhotic patients. Scandinavian journal of gastroenterology, 51(3), 344-353.
6. Hann H.-W., D. Li, H. Yamada, et al (2014). Usefulness of highly sensitive AFP-L3 and DCP in surveillance for hepatocellular carcinoma in patients with a normal Alpha-Fetoprotein. J Med Microb Diagn, 3(1), 1-6.
7. Ngô Thị Thanh Quýt, Nguyễn Phương, Lê Thành Lý, Bùi Hữu Hoàng (2010), “Chẩn đoán mức độ xơ hóa gan bằng phương pháp đo độ đàn hồi gan trên bệnh nhân bệnh gan mạn”, Tạp chí Y Học Thành phố Hồ Chí Minh, 14(1), tr.161-166.
8. Lâm Hoàng Cát Tiên (2005), Khảo sát giá trị của phương pháp chẩn đoán không xâm lấn trong xơ gan còn bù, Luận văn bác sĩ nội trú, Đại học Y Dược TP.Hồ Chí Minh.
9. Ivan G, Antonio B, Riccardo S. Diagnostic Accuracy of PIVKA-II, Alpha-Fetoprotein and a Combination of both in Diagnosis of Hepatocellular Carcinoma in Patients Affected by Chronic HCV Infection. In Vivo July 2017, 31 (4) 695-700