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Date Published: 28/08/2025
Abstract Views: 313
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DOI: https://doi.org/10.51298/vmj.v553i1.15266
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Vol. 553 No. 1 (2025)
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Các bài báo
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Quản Thu, T., Mai Thị, H., Nguyễn Hữu, D., & Lê Việt, T. (2025). SURVEYING NEUTROPHIL TO LYMPHOCYTE RATIO AND PLATELET TO LYMPHOCYTE RATIO ON MAINTENANCE HEMODIALYSIS PATIENTS. Vietnam Medical Journal, 553(1). https://doi.org/10.51298/vmj.v553i1.15266

SURVEYING NEUTROPHIL TO LYMPHOCYTE RATIO AND PLATELET TO LYMPHOCYTE RATIO ON MAINTENANCE HEMODIALYSIS PATIENTS

Thủy Quản Thu, Hiền Mai Thị, Dũng Nguyễn Hữu, Thắng Lê Việt

Main Article Content

Abstract

Objective: To investigate the Neutrophil/ Lymphocyte Ratio (NLR) and Platelet/Lymphocyte Ratio (PLR) and their associations with several clinical and paraclinical parameters in maintenance hemodialysis patients. Subjects and Methods: A descriptive, cross-sectional analytical study was conducted on 90 MHD patients and 30 age- and gender-matched healthy controls at Military Hospital 103 from September 2024 to June 2025. Clinical and paraclinical characteristics of the study subjects were collected, and NLR and PLR indices were calculated from peripheral cell blood count. Results: The NLR in the patient group was 3.1 (2.40 – 4.21), significantly higher than in the control group which was 1.86 (1.45 – 2.24) with p<0.001. The PLR in the patient group was 154.84 (119.66 – 201.92), significantly higher than in the control group which was 122.38 (96.62 – 149.0), with p=0.001. 43% of patients had elevated NLR, 11% had elevated PLR only, and 8% had simultaneous elevation of both indices. PCT (OR=3.69, p=0.027) was an independent factor associated with increased NLR, diabetes mellitus (OR=5.29, p=0.045) was an independent factor associated with increased PLR, and CRP (OR=1.189, p=0.026) was an independent factor associated with increased NLR and PLR. Conclusion: NLR and PLR increased in MHD patients. PCT, CRP, and diabetes mellitus were independent factors associated with NLR and PLR.

Article Details

Keywords

NLR, PLR, maintenance hemodialysis

References

1. Annual Data Report. USRDS, , accessed: 06/06/2025.
2. Tang S.C.W., Yu X., Chen H.C., et al. (2020). Dialysis Care and Dialysis Funding in Asia. Am J Kidney Dis, 75(5), 772–781.
3. Kalantar-Zadeh K., Ikizler T.A., Block G., et al. (2003). Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis Off J Natl Kidney Found, 42(5), 864–881.
4. Zhang J., Lu X., Wang S., et al. (2021). High Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Are Associated with Poor Survival in Patients with Hemodialysis. BioMed Res Int, 2021(1), 9958081.
5. Zhang Y., Zhang A., Wei L., et al (2023). A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients. Ren Fail, 45(2), 2258228.
6. Carrero J.J. and Stenvinkel P. (2010). Inflammation in end-stage renal disease--what have we learned in 10 years. Semin Dial, 23(5), 498–509.
7. Turkmen K., Erdur F.M., Ozcicek F., et al (2013). Platelet‐to‐lymphocyte ratio better predicts inflammation than neutrophil‐to‐ lymphocyte ratio in end‐stage renal disease patients.
8. Trịnh Văn Tài (2021), Nghiên cứu chỉ số Neutrophil/Lymphocyte và Platelet/Lymphocyte máu ngoại vi ở bệnh nhân bệnh thận mạn có chỉ định ghép thận, Luận văn thạc sỹ y học, Học viện Quân Y.
9. Yasemin K., Mehmet Y., et al (2019). Platelet Lymphocyte Ratio is Associated With Carotid Atherosclerosis in Hemodialysis Patients.
10. Li L., Shen Q., and Rao S. (2022). Association of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Study. Ther Clin Risk Manag, 18, 1157–1166.