THAY ĐỔI MỘT SỐ CHỈ SỐ SINH HÓA, HUYẾT HỌC VÀ NỒNG ĐỘ HBV-DNA Ở BỆNH NHÂN VIÊM GAN B MẠN, XƠ GAN VÀ UNG THƯ BIỂU MÔ TẾ BÀO GAN CÓ HBsAg (+)

Abstract

Objective: To describe the biochemical and hematological parameters and HBV-DNA levels in patients with chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC), all of whom were infected with the HBV. Methods: A descriptive, cross-sectional study was conducted on 429 HBsAg-positive patients, including 102 CHB patients, 96 LC patients, and 231 HCC patients. The participants were definitively diagnosed and received inpatient treatment at 103 Military Hospital and 108 Military Central Hospital. Results: The percentage of LC patients with high level of AST was 85.4% (higher than 73.0% in the HCC group and 73.8% in the CHB group). The percentages of HCC patients with elevated total bilirubin and decreased %Prothrombin were 24.6% and 11.0% respectively, which were significantly lower than those in the CHB and LC groups (p<0.05). A decrease in red blood cell and platelet counts was observed in 12.2% and 21.4% of chronic hepatitis B patients, respectively; these proportions were lower than those in the cirrhosis group (36.2% and 53.2%) and the HCC group (27.7% and 34.2%). Furthermore, the HBV-DNA levels >10⁴ copies/ml in patients with HCC, CHB and LC groups, accounting for 42.6%, 61.8% and 76.0% respectively. There were no differences in urea, creatinine, and blood glucose levels among the groups. Conclusion: Patients with HBV-Associated liver diseases exhibit significant alterations in biochemical and hematological parameters, highlighted by increased AST and decreased blood cell counts (red blood cells and platelets) in the cirrhosis and HCC groups. Meanwhile, high HBV-DNA levels, along with a significant decline in liver function (%Prothrombin and Total Bilirubin), were observed in CHB and LC groups.