MỐI LIÊN QUAN GIỮA BIẾN THỂ GEN NTCP S267F VÀ ĐẶC ĐIỂM CẬN LÂM SÀNG Ở BỆNH NHÂN VIÊM GAN B MẠN, XƠ GAN VÀ UNG THƯ BIỂU MÔ TẾ BÀO GAN CÓ HBsAg (+)

Abstract

Objectives: To evaluate the association between the NTCP S267F variant and specific paraclinical characteristics in patients with chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC) who are HBsAg (+). Subjects and Methods: A cross-sectional descriptive study was conducted on 429 patients infected with hepatitis B virus (HBV) who received treatment at the 103 Military Hospital and the 108 Military Central Hospital. The study groups included 102 patients with CHB, 96 with LC, and 231 with HCC. Results: HCC patients with the S267F variant (CT genotype) had a higher percentage of elevated GGT and lower HBV-DNA levels compared to CHB group with the same genotype (p<0.05). In the group with the wild-type NCTP (CC genotype), LC patients showed a significantly higher percentage of elevated AST (84.4%) than the CHB group (65.6%) (p<0.05). The majority of HCC patients with the CC genotype had total bilirubin and %prothrombin within normal ranges (77.5% and 89.5%, respectively), along with lower HBV-DNA levels and a higher proportion of AFP > 400 ng/mL compared to the LC and CHB groups. In subgroup analyses, no association was found between the NTCP S267F gene variant and biochemical parameters (AST, ALT, GGT, total bilirubin, prothrombin, Urea, Creatinine, and Glucose), hematological parameters (white blood cell, red blood cell, and platelet counts), or HBV-DNA and AFP levels. Conclusion: The GGT levels were significantly higher in HCC patients with the CT genotype compared to the CHB group with the same genotype, this difference was not observed in the group with the CC genotype. No direct association was found between the NTCP S267F variant and paraclinical parameters in HBV-Associated patients with CHB, LC or HCC.