MỐI LIÊN QUAN GIỮA HỘI CHỨNG CHUYỂN HOÁ VÀ MỨC ĐỘ NẶNG THOÁI HOÁ KHỚP GỐI TRÊN BỆNH NHÂN NỮ CAO TUỔI

Abstract

Background: Metabolic syndrome (MetS) is a potential risk factor associated with increased severity of knee osteoarthritis (KOA); however, there is a paucity of research specifically targeting older female populations in Vietnam. Objective: To investigate the prevalence of MetS and examine the association between MetS components and radiographic severity of KOA in women aged ≥60 years. Subjects and Methods: This was a cross-sectional descriptive study conducted from September 2024 to January 2025 at the Geriatrics Outpatient Clinic, University Medical Center Ho Chi Minh City. A total of 267 women aged ≥60 years diagnosed with KOA based on ACR 1986 criteria were included. MetS was defined according to the 2009 Joint Interim Statement criteria. Radiographic severity of KOA was assessed using the Kellgren–Lawrence (KL) grading system. Results: The prevalence of MetS among female patients with knee osteoarthritis was 66,3%. In patients with advanced KL stages, the prevalence of MetS, increased waist circumference, and elevated triglyceride levels was 76,9%, 86,2%, and 66,2%, respectively; all significantly higher than those observed in patients with early KL stages (56,2%, 73,0%, and 51,8%, respectively). In multivariate analysis adjusted for age and BMI, MetS (OR = 2,27; 95% CI: 1,29–4.00; p = 0,004) and elevated triglycerides (OR = 1,72; 95% CI: 1,04–2,85; p = 0,035) remained independently associated with severe KOA. Conclusion: The prevalence of MetS is high among older women with KOA. MetS, particularly elevated triglyceride levels, is independently associated with greater radiographic severity of KOA.