KẾT QUẢ KIỂM SOÁT GLUCOSE MÁU Ở TRẺ ĐÁI THÁO ĐƯỜNG SƠ SINH TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Glycemic control (GC) is the primary goal for the regulation and management of diabetes. Good glycemic control for children with neonatal diabetes mellitus (NDM) helps prevent complications. Objectives: Review the results of GC in NDM children at the National Children's Hospital. Method: Cases series report. Results: 94.1% of patients carrying ABCC8/KCNJ11 mutations achieved good GC levels when treated with SU, one patient with undetected mutant genes treated with SU had good baseline blood glucose levels, when converted to insulin had good blood glucose levels but poor HbA1c. When treated with insulin, 37.5% (HbA1c-based) and 25% (blood-glucose-based) patients with other gene mutations reached the GMG target. 2/7 patients without genetic mutations were stopped but had to restart insulin during acute infections. 100% of patients with 6q24 abnormality had a good GC before stopping the drug, no patients had relapsed. There were no patients with severe hypoglycaemia, asymptomatic hypoglycaemia was seen mainly in insulin-treated patients.