MỐI LIÊN QUAN GIỮA NỒNG ĐỘ OSTEOPROTEGERIN VỚI ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG Ở BỆNH NHÂN NHỒI MÁU CƠ TIM CẤP

Abstract

Objectives: To investigate the relationship between serum OPG levels and clinical, paraclinical characteristics in patients with acute myocardial infarction (AMI). Methods: We enrolled 135 acute MI patients underwent percutaneous coronary intervention at Cardiovascular Intervention Department – 103 Military Hospital from 02/2021 to 04/2023 and 50 control subjects without coronary artery disease. Testing serum OPG levels at the time of admission, evaluating the relationship between OPG levels and clinical, paraclinical characteristics. Result: OPG concentration in patients with AMI was significantly higher than that in the control group (2323.63 ± 2276.23 pg/ml vs. 1424.24 ± 456.74 pg/ml, p < 0,001). In the MI group, patients admitted early (≤ 12h) had signficantly lower OPG concentrations than patients admitted late (> 12h); levels of serum OPG had a strong positive correlation with age (r = 0.527, p < 0.001), a moderate positive correlation with Troponin I (r = 0,346, p < 0.001), CK – MB (r = 0,323, p < 0.001) and NT-proBNP (r = 0.337, p < 0.001). Patients with multivessel coronary artery lesions had significantly higher OPG levels than those with single vessel lesions (2450.37 ± 696.99 vs 2127.53 ± 664.49 pg/ml, p < 0.05). Conclusion: Patients admitted early (≤ 12h) had signficantly lower OPG concentrations than patients admitted late (> 12h). Levels of serum OPG had a positive correlation with age, Troponin I, CK-MB and NT-proBNP. Patients with multivessel coronary artery lesions had significantly higher OPG levels than those with single vessel lesions.