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RESEARCH ON THE IMPORTANCE OF GPR INDEX IN PROGNOSIS OF THE DEGREE OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS CAUSED BY OCCUPATIONAL TRINITROTOLUENE POISONING
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Abstract
Objective: To evaluate the GPR index in predicting the degree of liver fibrosis in patients with chronic hepatitis due to occupational trinitrotoluene poisoning. Subjects and Methods: 177 patients were diagnosed with chronic hepatitis due to occupational exposure to TNT; descriptive cross-sectional study; whole sample collection: biopsy for histopathology, biochemical and hematological tests; liver degeneration stage according to Metavir; GPR index. Results: Patients in group F0 (55.9%), F1 (36.2%), F2 (7.9%); The average GPR index was 0.48 ± 0.57, the lowest was 0.05, the highest was 5.93; The GPR index in group F1 (0.71 ± 0.78) was higher than that in group F0 (0.30 ± 0.15), p < 0.001; patients in group F2 had the highest GPR index (1.45 ± 0.34), the lowest was group F0 (0.30 ± 0.15), (p<0.05); The GPR index in group F ≥ 1 (0.71 ± 0.78) was higher than that in group F0 (0.30 ± 0.15), p < 0.001; There was a positive correlation between GPR index and liver fibrosis stages (r = 0.428 and p < 0.001). Conclusion: GPR in group F ≥ 1 was higher than group F0, group F ≥ 2 was higher than group F < 2 (p < 0.05). There was a positive correlation between GPR and liver fibrosis stages according to Metavir (p < 0.05).
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Keywords
GPR, Liver fibrosis, Trinitrotoluene.
References
2. Subasi C.F., Aykut U.E., Yilmaz Y. Comparison of noninvasive scores for the detection of advanced fibrosis in patients with nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol, 2015, 27(2): 137-41.
3. Yang H.R., Kim H.R., Myung J.K. et al. Noninvasive parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease. World journal of gastroenterology, 2012, 18(13): 1525-1530.
4. Ghachem I., Hamzaoui L., Bachali A., et al. Performance of GPR score for non-invasive assessment of liver fibrosis in chronic hepatitis B Tunisian patients.Tunis Med, 2024,102(10):715-721.
5. Chowdhury A.B., Mehta K.J. Liver biopsy for assessment of chronic liver diseases: a synopsis. Clin Exp Med, 20232, 3(2): 273-285.
6. Nguyễn Phúc Thái. Nghiên cứu lâm sàng, cận lâm sàng tổn thương gan do tiếp xúc nghề nghiệp với trinitrotoluen và thăm dò tác dụng bảo vệ của cà gai leo trên thực nghiệm, Luận án Tiến sĩ Y học, Học viện Quân y. 1998.
7. Nwokediuko S.C., Ibegbulam O. Quantitative Platelet Abnormalities in Patients With Hepatitis B Virus-Related Liver Disease. Gastroenterology Res, 2009, 2(6): 344-349.
8. Ben A.H., Koubaa M., Yaich S., et al. A new combined predicting model using a non-invasive score for the assessment of liver fibrosis in patients presenting with chronic hepatitis B virus infection. Med Mal Infect, 2019, 49(8): 607-615.
9. Lemoine M., Shimakawa Y., Nayagam S., et al. The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa. Gut, 2016, 65(8): 1369-76.
10. Huang R., Wang G., Tian C., et al. Gamma-glutamyl-transpeptidase to platelet ratio is not superior to APRI,FIB-4 and RPR for diagnosing liver fibrosis in CHB patients in China. Sci Rep, 2017, 7(1): 8543.