EARLY SURGICAL OUTCOMES OF DIFFERENTIATED THYROID CARCINOMA WITH LATERAL CERVICAL LYMPH NODE METASTASES AT K HOSPITAL

Thanh Tùng Phạm, Xuân Quý Ngô, Mạnh Thắng Hoàng, Quốc Duy Ngô, Đức Toàn Trần

Main Article Content

Abstract

Objective: To evaluate the early surgical outcomes in patients with differentiated thyroid carcinoma with lateral cervical lymph node metastases. Materials and Methods: A cross-sectional descriptive study was conducted on 123 patients diagnosed with DTC with lateral neck lymph node metastases and treated at K Hospital from November 2022 to November 2024. Results: The male-to-female ratio was 1:3, with a mean age of 44.63 ± 12.87 years. Incidental tumor detection accounted for 69.9% of cases. Tumors located in a single thyroid lobe were observed in 69.1% of patients, and tumors ≤2 cm in size were found in 70.7%. Ipsilateral cervical lymph node metastasis occurred in 88.6% of cases, with 59.3% of metastatic nodes having a short-axis diameter ≥10 mm. Hospital stays of less than 10 days accounted for 97.6% of patients. Postoperative histopathology showed that papillary thyroid carcinoma accounted for 99.2% of cases, and 15.4% had no metastasis in central neck lymph nodes. At 72 hours post-surgery, complications included recurrent laryngeal nerve (RLN) injury in 32.5%, hypoparathyroidism in 20.3%, and chyle leak in 8.9%. These complications gradually improved, with most being temporary. Surgical outcomes were rated as good in 87.8% of patients at 1 month postoperatively and 97.6% at 6 months. Conclusion: Surgery for differentiated thyroid carcinoma with lateral cervical lymph node metastases provides favorable early outcomes and demonstrates high safety.

Article Details

References

1. Lyu Z, Zhang Y, Sheng C, Huang Y, Zhang Q, Chen K. Global burden of thyroid cancer in 2022: Incidence and mortality estimates from GLOBOCAN. Chin Med J (Engl). 2024 Nov 5;137(21):2567-2576.
2. Baud G, Jannin A, Marciniak C, et al. Impact of Lymph Node Dissection on Postoperative Complications of Total Thyroidectomy in Patients with Thyroid Carcinoma. Cancers (Basel). 2022;14(21):5462.
3. Rocke DJ, Mulder H, Cyr D, et al. The effect of lateral neck dissection on complication rate for total thyroidectomy. Am J Otolaryngol. 2020; 41(3):102421.
4. Lim J, Lee HS, Heo JH, Song YS. Clinicopathological Features and Molecular Signatures of Lateral Neck Lymph Node Metastasis in Papillary Thyroid Microcarcinoma. Endocrinol Metab (Seoul). 2024;39(2):324-333.
5. Lê Văn Long. Đánh giá kết quả sớm phẫu thuật ung thư tuyến giáp tại bệnh viện K năm 2017, Luận văn Thạc sĩ y học, Trường Đại học Y Hà Nội. 2018
6. Nguyễn Thị Bích Ngọc. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng hạch cổ di căn của ung thư biểu mô tuyến giáp thể nhú tại bệnh viện Bạch Mai, Luận văn Thạc sĩ y học, Trường Đại học Y Hà Nội. 2014
7. Lê Văn Quảng, Ngô Quốc Duy, Mai Thế Vương, và cộng sự. Đánh giá các yếu tố ảnh hưởng tới tình trạng di căn hạch nhóm 6 ở bệnh nhân vi ung thư biểu mô tuyến giáp thể nhú giai đoạn cN0. Tạp chí Ung thư học Việt Nam, Số 1 – 2019.
8. Polistena A, Ranalli M, Avenia S, et al. The Role of IONM in Reducing the Occurrence of Shoulder Syndrome Following Lateral Neck Dissection for Thyroid Cancer. J Clin Med. 2021;10(18):4246. Published 2021 Sep 18.