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VALUES OF CYSTATIN C IN EARLY DIAGNOSIS OF RENAL DISEASE IN PATIENTS WITH TYP 2 DIABETES IN THAINGUYEN NATIONAL HOSPITAL
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Abstract
Diabetic kidney disease (diabetes mellitus) is a small vascular complication that occurs early, with a high rate, is the cause of end-stage renal failure requiring periodic dialysis, early detection of the decrease in filtration Glomerular glomeruli for diabetic patients is extremely necessary. Objective: Determine the value of plasma cystatin C in early detection of kidney damage in type 2 diabetes patients. Subjects and research methods: Cross-sectional description of 89 type 2 diabetic patients on external treatment residing at the Department of Medical Examination of ThaiNguyen National Hospital. Results: There is a close correlation between the concentration of cystatinC and creatinin plasma, between eGFRcys and eGFRcre in type 2 diabetes; There is a strong inverse correlation between the concentration of cystatin C and MLCTcre in patients with type 2 diabetes; Estimating GFR by cystatin C increased by 25% (13/89) patients with renal impairment (eGFR<60 ml/p). Analyze the ROC curve with critical value of GFR 60 ml / min. The AUC of cystatin C of 0.812 is greater than that of creatinine AUC of 0.711. The difference was statistically significant (p <0.05); Conclusions: Plasma cystatin C may reflect an early decrease in glomerular filtration rate in type 2 diabetic patients.
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Keywords
CystatinC, diabetic nephropathy, estimated glomerular filtration rate (eGFR)
References
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