KẾT QUẢ ĐIỀU TRỊ HELICOBACTER PYLORI BẰNG PHÁC ĐỒ PALB Ở BỆNH NHÂN VIÊM LOÉT DẠ DÀY-TÁ TRÀNG

Abstract

Background: Helicobacter pylori infection remains a current and globally relevant issue, garnering attention both nationally and internationally. In Vietnam, resistance rates to clarithromycin, metronidazole, and levofloxacin have surpassed the acceptable thresholds for traditional triple therapy regimens. Meanwhile, the PALB regimen has emerged as a potential alternative. However, clinical data on the PALB regimen remain limited in Vietnam, particularly in the Mekong Delta region. Objective: To evaluate the efficacy of the PALB regimen in eradicating Helicobacter pylori (H. pylori) in patients with peptic ulcer disease. Materials and methods: This was a cross-sectional descriptive study with analytical components conducted on 71 patients with peptic ulcer disease infected with H. pylori, treated using the PALB regimen at Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital. Results: All 71 patients completed the PALB regimen and underwent follow-up endoscopy after 6 weeks. Post-treatment, clinical symptoms including epigastric pain, burning sensation, heartburn, acid reflux, bloating, indigestion, and anorexia showed significant improvement (p < 0.05). The prevalence of gastroduodenitis upon follow-up endoscopy was 19.4%, significantly reduced from 100% at baseline (p < 0.001). Although the rate of gastric and duodenal ulcers improved, the difference was not statistically significant (p = 0.5). The eradication rate of H. pylori as confirmed by follow-up endoscopy was 73.2%. The most frequently reported adverse effect was anorexia (11.3%), followed by dark-colored stools (8.5%), and dry mouth and bitter taste (each 4.2%). Headache and diarrhea occurred in 2.8% of patients, while insomnia was noted in 1.4%. Conclusion: The H. pylori eradication rate of the PALB regimen was within an acceptable range. This regimen may be considered in appropriate clinical contexts; however, broader implementation should await local antibiotic susceptibility data.