LACTATE MÁU Ở BỆNH NHÂN VIÊM PHỔI CỘNG ĐỒNG THỞ MÁY TẠI KHOA HỒI SỨC NHIỄM BỆNH VIỆN NHI ĐỒNG 1

Abstract

Objective: To determine the role of blood lactate concentration in children with severe pneumonia on mechanical ventilation. Method: This is a prospective observational, cross-sectional study design on 35 children from 1 month to under 16 years old with severe pneumonia requiring invasive mechanical ventilation, treated at the Department of Infectious Diseases Resuscitation - Children's Hospital 1 from December 2023 to the end of September 2024. Blood lactate concentration, OI index, other oxygenation indices were measured at T0 (immediately after intubation), T6, T24, and T48-hour. At the same time, complications of pneumonia were also recorded within 48 hours after intubation. Results: 35 children meeting the inclusion criterias were included in the study, with the following results: The age of admission was mainly concentrated in the group of 2-month - < 12-months old (57.1%). The rate of increased blood lactate in the study subjects was highest at T0 34.3%, followed by T24 25.7% and T48 22.9%. Blood lactate concentration had a statistically significant difference between the group with pneumonia complications and the group without pneumonia complications at T24 and T48, and blood lactate concentration was also most highly correlated with mortality at T24 with AUC = 0.84. Conclusion: Elevated blood lactate plays a prognostic role in children with community-acquired pneumonia requiring mechanical ventilation.