PROGNOSTIC VALUE OF THE MELD SCORE IN PREDICTING ACUTE LIVER FAILURE RISK IN CIRRHOTIC PATIENTS TREATED AT THANH BA MEDICAL CENTER

Quốc Tuấn Lê, Trường Cửu Vương

Main Article Content

Abstract

Objective: To evaluate the prognostic value of the MELD score in predicting the risk of acute liver failure in cirrhotic patients treated at Thanh Ba Medical Center. Subjects and Methods: A prospective study was conducted on 52 cirrhotic patients, divided into two groups: with and without acute liver failure. The MELD score was calculated and analyzed for its association with the risk of acute liver failure. Results: Patients with acute liver failure had a significantly higher mean MELD score than those without (22.4 ± 3.1 vs. 15.2 ± 2.8; p < 0.01). A MELD threshold of ≥18 had a sensitivity of 85% and a specificity of 78% for predicting acute liver failure. When MELD ≥20, specificity increased to 85.1%. Conclusion: The MELD score has high prognostic value in predicting acute liver failure risk in cirrhotic patients. A MELD threshold of ≥18 enables early identification of high-risk patients, facilitating timely treatment and reducing mortality rates

Article Details

References

1. European Association for the Study of the Liver (EASL). "Acute-on-chronic liver failure: consensus recommendations of the EASL-CLIF Consortium." Journal of Hepatology, 2023.
2. Jalan, R., et al. "Acute liver failure and chronic liver disease: A prospective study of outcomes and risk factors." The Lancet Gastroenterology & Hepatology, 2022.
3. Kamath, P. S., et al. "A model to predict survival in patients with end-stage liver disease." Hepatology, 2021.
4. Moreau, R., et al. "Acute-on-chronic liver failure: a distinct syndrome that predicts mortality in patients with acute decompensation of cirrhosis." Gastroenterology, 2013.
5. Nguyễn Văn Tuấn và Tạ Thị Diệu Ngân, “Giá trị của thang điểm Child Pugh, MELD và MELD-Na trong tiên lượng tử vong ở bệnh nhân xơ gan mất bù do viêm gan virus B”, Tạp chí Nghiên cứu Y học, 531 (1B), 2023, tr 361-365.
6. Nguyễn Thị Thu Hải và Bùi Hữu Hoàng. “Giá trị của thang điểm MELD và mô hình AE trong dự đoán suy gan cấp trên nền mạn ở bệnh nhân viêm gan vi rút B mạn đợt bùng phát nặng”. Tạp chí Nghiên cứu Y học, 545 (2), 2024, tr157-160.
7. Biggins, S. W., et al. "Evidence-based incorporation of serum sodium concentration into MELD." Gastroenterology, 2006.