ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ YẾU TỐ LIÊN QUAN CỦA MÀY ĐAY MẠN TÍNH TỰ PHÁT CÓ PHÙ MẠCH

Abstract

Chronic spontaneous urticaria (CSU) is a common skin disease, with angioedema as a notable clinical manifestation that can influence disease severity and prognosis. We conducted a cross-sectional, prospective study of 900 CSU patients attending the Urticaria Clinic of the National Hospital of Dermatology and Venereology from October 2024 to May 2025 to describe the clinical and laboratory characteristics of patients with angioedema and compare them with those without angioedema. The prevalence of angioedema was 36.2%, most commonly affecting the lips (89%) and eyelids (51.8%), and was generally spontaneous and mild. Compared with the non-angioedema group, patients with angioedema had higher total IgE levels (214.5 vs. 153.8 IU/mL; p<0.001), higher CRP levels (1.3 vs. 0.89 mg/L; p=0.041), and higher rates of elevated IgE (83.1% vs. 68.0%; p<0.001), elevated CRP (16.9% vs. 10.2%; p=0.016), and positive ASST (72.8% vs. 60.8%; p=0.047). Multivariate logistic regression identified elevated IgE (OR=2.19) and elevated UAS7 (OR=1.04) as independent predictors of angioedema. These findings suggest a combined type 1 and type 2b pathogenic mechanism in CSU with angioedema.