ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ CÁC YẾU LIÊN QUAN CỦA MÀY ĐAY MẠN TÍNH Ở TRẺ EM

Abstract

Objective: Describe and compare clinical and laboratory characteristics of chronic urticaria between children and adults. Subjects and method: A cross-sectional study was conducted on 364 children and 1210 adults (aged 16 to 60) diagnosed and classified according to the EAACI/GA²LEN/EuroGuiDerm/ APAAACI 2022 guidelines at the Urticaria and Chronic Urticaria Clinic, Central Dermatology Hospital from February 2023 to July 2025. Results: Isolated chronic spontaneous Urticarial (isCSU) was the predominant phenotype in both groups and significantly higher than in children (93.41% vs. 75.54%, p<0.001). Children had a nearly equal male-to-female ratio, shorter disease duration, lower UAS7 scores, and milder disease severity than adults. The rate of angioedema in children was higher than in adults  (44.23% vs. 30.33%, p<0.001). Adults had higher rates of thyroid disease, autoimmune disease, CRP levels, and anti-TPO levels, but the number of patients with increased CRP and anti-TPO was much higher than in children. Children had higher eosinophil counts and IgE levels, but the number of patients with increased IgE was lower. Psychological stress was identified as an aggravating factor only in adults. Conclusion: CU in children and adults differs significantly in epidemiology, clinical presentation, and laboratory features, reflecting underlying pathophysiological distinctions and necessitating age-specific diagnostic and therapeutic approaches.