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Date Published: 02/12/2025
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DOI: https://doi.org/10.51298/vmj.v556i1.16260
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Vol. 556 No. 1 (2025)
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Các bài báo
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Phạm, T. L., & Bùi, T. Đức. (2025). ASSOCIATION OF PR INTERVAL WITH VENTRICULAR ARRHYTHMIA RISK IN PATIENTS WITH A BRUGADA ECG PATTERN. Vietnam Medical Journal, 556(1). https://doi.org/10.51298/vmj.v556i1.16260

ASSOCIATION OF PR INTERVAL WITH VENTRICULAR ARRHYTHMIA RISK IN PATIENTS WITH A BRUGADA ECG PATTERN

Trần Linh Phạm, Trung Đức Bùi

Main Article Content

Abstract

Background: Brugada syndrome is an inherited arrhythmia with risk of nocturnal sudden cardiac death (SCD) from ventricular fibrillation (VF). The value of electrophysiology (EP) for SCD risk stratification remains debated. The surface-ECG PR interval may help identify higher-risk patients. Objectives: (1) Describe PR intervals in patients with a Brugada ECG pattern; (2) assess their association with ventricular arrhythmia (VA) inducibility. Methods: Cross-sectional study of 47 consecutive patients with a Brugada ECG pattern at the Vietnam National Heart Institute–Bach Mai Hospital. All underwent 12-lead ECG, echocardiography, laboratory testing, clinical/family history taking, and an EP study. The primary endpoint was inducible VT/VF. Results: Mean age was 49 ± 13 years; 95.7% were male. EP testing induced VT/VF in 31/47 patients (66%). PR intervals were significantly longer in EP-positive than EP-negative patients, particularly in leads V1 and V6. A PR interval in V5 ≥ 158.3 ms provided the best prediction of inducible VA. Conclusions: In patients with a Brugada ECG pattern, longer PR intervals on the surface ECG are associated with inducible life-threatening ventricular arrhythmias and may aid risk stratification.

Article Details

Keywords

Brugada syndrome, PR interval, risk stratification.

References

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