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STUDY THE LEFT ATRIAL MORPHOLOGICAL CHARACTERISTICS, PLASMA CONCENTRATIONS OF MATRIX METALLOPROTEINASE-2, OSTEOPONTIN AND NT-PROBNP IN ATRIAL FIBRILLATION PATIENT TREATED BY RADIOFREQUENCY ABLATION
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Abstract
Objective: Survey of left atrial morphological characteristics, NT-proBNP, Matrix Metalloproteinase-2 (MMP-2) and Osteopontin (OPN) concentrations in patients with atrial fibrillation (AF) indicated for radiofrequency ablation (RFA). Subjects and methods: Cross-sectional descriptive study in 110 AF patients, treated by RFA at 103 Military Hospital, Bach Mai Hospital, Hanoi Heart Hospital from January 2021 to December 2024. Results: The LAD in patients with persistent AF was statistically significantly larger than that in patients with paroxysmal AF. The LAD on echocardiography and CT images were positively correlated. NT-proBNP concentration had a moderate positive correlation with LAD; this concentration was higher in the group with dilated left atrium than in the group with normal left atrium, the difference was statistically significant. MMP-2 and OPN concentrations had a weak positive correlation with LAD on echocardiography, tending to be higher in the group with dilated left atrium than in the group with normal left atrium. NT-proBNP and MMP-2 had a moderate positive correlation. Conclusion: The LAD in persistent AF patients was larger than that in paroxysmal AF group. NT-proBNP and MMP-2 concentrations were positively correlated; NT-proBNP, MMP-2, and OPN tended to be higher in the group of patients with AF with dilated left atrium.
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Keywords
Atrial fibrillation, left atrial diameter, NT-proBNP, MMP-2, OPN, RFA.
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