LIÊN QUAN GIỮA CHỨC NĂNG GAN TRƯỚC GHÉP VÀ RỐI LOẠN ĐÔNG MÁU SỚM SAU GHÉP GAN

Abstract

Objective: This study aimed to evaluate the correlation between pre-transplant liver function and basic coagulation parameters after liver transplantation. Methods: A descriptive study, combining both prospective and retrospective designs, was conducted on 144 liver transplant recipients at the 108 Military Central Hospital, from June 2020 to June 2025. Pre-transplant liver function parameters included the Model for End-Stage Liver Disease (MELD) score, Child-Pugh score, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen level, and platelet count. Coagulation parameters were monitored daily during the first 7 postoperative days. Results: Coagulation disorders were common during the first postoperative week, particularly in patients with poor baseline liver function. Pre-transplant MELD and Child-Pugh scores showed a negative correlation with PT and platelet count, and a positive correlation with APTT. Patients with severe postoperative coagulopathy had significantly higher MELD and Child-Pugh scores and lower platelet counts (p < 0.05). Conclusion: Pre-transplant liver function is closely associated with the severity of postoperative coagulopathy. Assessing these parameters before transplantation may help predict outcomes and guide postoperative management planning.