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EVALUATE THE RELATIONSHIP BETWEEN LEFT ATRIAL MORPHOLOGY, PLASMA CONCENTRATIONS OF MATRIX METALLOPROTEINASE-2, OSTEOPONTIN, NT-PROBNP, CLINICAL, PARACLINICAL CHARACTERISTICS AND RESULTS OF RADIOFREQUENCY ABLATION IN ATRIAL FIBRILLATION PATIENTS
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Abstract
Objective: Survey of the relationship between left atrial morphology, NT-proBNP, Matrix Metalloproteinase-2 (MMP-2), Osteopontin (OPN) concentrations, clinical and paraclinical characteristics and treatment outcomes of patients with atrial fibrillation (AF) treated by radiofrequency ablation (RFA). Subjects and methods: Cross-sectional descriptive study, longitudinal follow-up of 110 RN patients, treated with RFA at 103 Military Hospital, Bach Mai Hospital, Hanoi Heart Hospital from January 2021 to December 2024. Results: After 3 months of RFA, the sinus rhythm maintenance rates in the general group, the paroxysmal AF group, and the persistent AF group were 77.78%, 89.74%, and 50%, respectively. After 6 months of RFA, the sinus rhythm maintenance rates were 77.78%, 89.74%, and 46.67%, respectively. Patients with recurrent AF at all follow-up time points had significantly larger LAD and NT-proBNP concentrations than those in the sinus rhythm maintenance group. MMP-2 and OPN concentrations in this group tended to be higher than those in the sinus rhythm maintenance group, but the difference was not statistically significant. Conclusion: The group of patients with recurrent AF had significantly larger LAD and NT-proBNP levels than the group that maintained sinus rhythm. MMP-2 and OPN levels tended to be higher in the group with recurrent AF than in the group that maintained sinus rhythm.
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Keywords
Atrial fibrillation, left atrial morphology, NT-proBNP, MMP-2, OPN, RFA
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