EVALUATION OF PELVIC LYMPH NODE METASTASIS RATE IN CERVICAL CANCER PATIENTS UNDERGOING SURGERY AT THE NATIONAL HOSPITAL OF OBSTETRICS AND GYNECOLOGY

Văn Thắng Nguyễn, Đức Hà Nguyễn, Minh Hưng Đào, Hữu Hoàng Minh Nguyễn

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Abstract

Objective: To evaluate the rate and associated factors of pelvic lymph node metastasis in cervical cancer patients undergoing radical surgery at the National Hospital of Obstetrics and Gynecology. Subjects and Methods: A retrospective cross-sectional study was conducted on 445 patients with stage I–IIA cervical cancer who underwent surgery between 2020 and 2024. Results: The rate of pelvic lymph node metastasis was 15.3%. Significant associated factors included lymphovascular space invasion (OR: 13.5; p < 0.001), stromal invasion > 5 mm (OR: 4.99; p = 0.001), pelvic lymph nodes ≥ 1 cm detected on MRI (OR: 6.42; p < 0.001), and FIGO 2018 stage ≥ IB2 (OR: 1.95; p = 0.012). Conclusion: The incidence of pelvic lymph node metastasis in cervical cancer patients undergoing radical surgery at the National Hospital of Obstetrics and Gynecology is 15.3%. Prognostic factors associated with the risk of pelvic lymph node metastasis include lymphovascular space invasion (LVSI), pelvic lymph node size greater than 10 mm on MRI, and the preoperative clinical stage. Preoperative assessment of these factors may facilitate the indication for sentinel lymph node biopsy and aid in the selection of an optimal treatment strategy.

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References

Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249. doi:10.3322/caac.21660
2. Landoni F, Maneo A, Colombo A, et al. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 1997;350(9077): 535-540. doi:10.1016/ S0140-6736(97)02250-2
3. Joo JH, Kim YS, Nam JH. Prognostic significance of lymph node ratio in node-positive cervical cancer patients. Medicine (Baltimore). 2018;97(30): e11711. doi:10.1097/MD. 0000000000011711
4. Sun X, He L, Wang S. Risk factors for pelvic lymph node metastasis in cervical cancer: a retrospective analysis of 186 patients. Front Oncol. 2025;15:1525946. doi:10.3389/fonc.2025. 1525946
5. Shimada M, Kigawa J, Nishimura R, et al. Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol. 2006;101(2):234-237. doi:10.1016/j.ygyno.2005.10.004
6. Cibula D, Raspollini MR, Planchamp F, et al. ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer - Update 2023. Int J Gynecol Cancer. 2023;33(5):649-666. doi:10.1136/ijgc-2023-004429
7. Benedet JL, Bender H, Jones H, Ngan HY, Pecorelli S. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet. 2000;70(2):209-262.
8. Choi HJ, Roh JW, Seo SS, et al. Comparison of the accuracy of magnetic resonance imaging and positron emission tomography/computed tomography in the presurgical detection of lymph node metastases in patients with uterine cervical carcinoma: a prospective study. Cancer. 2006;106(4):914-922. doi:10.1002/cncr.21641