SURGICAL OUTCOMES OF SACROCOCCYGEAL GERM CELL TUMORS IN AT CHILDREN HOSPITAL 2

Trần Bản Hồ, Thị Mỹ Linh Nguyễn, Hoàng Vĩnh Kha Mai, Khánh An Chu, Kim Kha Võ , Quang Minh Trần, Thị Mai Quỳnh Tống, Thị Cẩm Quỳnh Tống, cc Võ , Võ Đức Tân Trần, Sĩ Phong Lê, Trường Nhân Vũ, Thị Vũ Quỳnh Huỳnh

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Abstract

Objective: Evaluation of outcomes of surgical treatment for sacrococcygeal germ cell tumors in children. Materials and methods: This retrospective descriptive case series includes all pediatric patients under 16 years old diagnosed with sacrococcygeal germ cell tumors (GCTs) and treated surgically at Children's Hospital 2 from January 1, 2018 to December 31, 2024. Results: We recorded 34 patients meeting the inclusion criteria. All patients underwent complete tumor resection along with partial coccygectomy, primarily via a retrorectal surgery (91,2%). Tumor rupture was the most frequent intraoperative complication (23,5%). Lymph node biopsy was performed in 2 cases (5,9%). The most frequent postoperative complication was surgical site infection, occurring in 9 cases (26,5%), whereas 67,6% of patients experienced no operative complications. One patient (2,9%) required a second surgery due to tumor recurrence. Stage I and low-risk tumors accounted for 94,1% of cases. 5 patients (14,7%) received surgery combined chemotherapy. All patients undergoing surgery alone achieved complete response. The study reported 1 case of recurrence (2,9%) and no cases of mortality. Conclusion: Surgery is the main treatment approach with low rates of complications and recurrence.

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References

1. Göbel U, Schneider DT, Calaminus G, et al (2023). Germ-cell tumors in childhood and adolescence. Annals of Oncology. 2000;11(3): 263-272. doi:10.1023/A:1008360523160
2. Rochín-Benoit A, Rascón-Alcántar A, Pérez-Borbón G (2023). Sacrococcygeal teratoma. Case report. Bol Clin Hosp Infant Edo Son. 2023;40(1):28-31. Accessed August 1, 2024. https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=111309
3. Poynter JN, Amatruda JF, Ross JA. (2010). Trends in incidence and survival of pediatric and adolescent patients with germ cell tumors in the United States, 1975 to 2006. Cancer. 2010;116(20):4882-4891. doi:10.1002/cncr.25454
4. Đào Thị Thanh An, Trần Diệp Tuấn. (2023). Đặc điểm chẩn đoán và điều trị u tế bào mầm ác tính ngoài sọ tại Bệnh viện Nhi đồng 2. Tạp chí Y học Việt Nam. 2023;527(1):340-344.
5. Nguyễn Thị Thủy Tiên, Phạm Duy Hiền, Trần Xuân Nam, Phan Hồng Long. (2024). Kết quả điều trị phẫu thuật u quái cùng cụt ở trẻ em tại Bệnh viện Nhi Trung Ương. Tạp chí Y học Việt Nam. 2024;534(1). doi:10.51298/vmj.v534i1.8035
6. Rescorla FJ, Sawin RS, Coran AG, et al (1998). Long-term outcome for infants and children with sacrococcygeal teratoma: a report from the Childrens Cancer Group. J Pediatr Surg. 1998; 33 (2):171-176. doi:10.1016/s0022-3468(98) 90426-2
7. Hasan S, Çeltik Ü, Şakul G, Çelik A, Ergün M. Germ Cell (2024). Neoplasms of Sacrococcygeal Region: Clinical Characteristics, Outcomes and Analysis of Recurrence after Treatment; A Comprehensive 20-Year Single Center Study. J Pediatr Res. 2024;11(3): 149-154. doi:doi:10. 4274/jpr.galenos.2024.83669
8. Bilik R, Shandling B, Pope M, Thorner P, Weitzman S, Ein S. (1993). Malignant benign neonatal sacrococcygeal teratoma. J Pediatr Surg. 1993;28(9): 1158-1160. doi:10.1016/0022-3468 (93)90154-d