Article Sidebar

pdf
Date Published: 15/12/2025
Abstract Views: 0
Views pdf: 0
DOI: https://doi.org/10.51298/vmj.v556i3.16501
Issue
Vol. 556 No. 3 (2025)
Section
Các bài báo
How to Cite
Trịnh , T. S. (2025). EVALUATION OF OOCYTE QUANTITY AND QUALITY OF THE PROTOCOL: RANDOM START OVARIAN STIMULATION USING PROGESTIN IN INFERTILE WOMEN. Vietnam Medical Journal, 556(3). https://doi.org/10.51298/vmj.v556i3.16501

EVALUATION OF OOCYTE QUANTITY AND QUALITY OF THE PROTOCOL: RANDOM START OVARIAN STIMULATION USING PROGESTIN IN INFERTILE WOMEN

Thế Sơn Trịnh

Main Article Content

Abstract

Objective: To evaluate the quantity and quality of oocytes retrieved using the protocol random start ovarian stimulation using progestin (Random-start PPOS). Subjects and Methods: This was a retrospective descriptive study conducted at the Military Institute of Clinical Embryology and Histology - Vietnam Military Medical University and Viet Bi Fertility and Andrology Hospital from January 2024 to April 2025. A total of 65 couples of reproductive age undergoing in vitro fertilization treatment using the Random-start PPOS protocol were recruited. Exogenous gonadotropins and progestin were administered at any time point during the menstrual cycle. Oocyte maturation was triggered with GnRHa, followed by oocyte retrieval, and the oocyte yield and fertilization rate after ICSI were assessed. The quantity and quality of retrieved oocytes were assessed. Results: The mean age of the study participants was 34.40 ± 6.04 years. The average duration of ovarian stimulation was 9.81 ± 1.29 days, with an initial FSH dose of 247.92 ± 51.37 IU/day. Oocyte retrieval efficiency was favorable, yielding an average of 9.47 ± 7.22 oocytes, of which 6.77 ± 5.46 were mature oocytes, and achieving a fertilization rate of 79%. Conclusion: The Random Start ovarian stimulation using progestin protocol shows promising potential for retrieving a good quantity of oocytes and achieving favorable fertilization rates in infertile women undergoing in vitro fertilization.

Article Details

Keywords

ovarian stimulation, random start, PPOS.

References

De Geyter C., Wyns C., Calhaz-Jorge C. và cộng sự. (2020). 20 years of the European IVF-monitoring Consortium registry: what have we learned? A comparison with registries from two other regions. Hum Reprod Oxf Engl, 35(12), 2832–2849.
2. Cakmak H., Katz A., Cedars M.I. và cộng sự. (2013). Effective method for emergency fertility preservation: random-start controlled ovarian stimulation. Fertil Steril, 100(6), 1673–1680.
3. Wang Y., Chen Q., Wang N. và cộng sự. (2016). Controlled Ovarian Stimulation Using Medroxyprogesterone Acetate and hMG in Patients With Polycystic Ovary Syndrome Treated for IVF: A Double-Blind Randomized Crossover Clinical Trial. Medicine (Baltimore), 95(9), e2939.
4. Huang H., Itaya Y., Samejima K. và cộng sự. (2022). Usefulness of random-start progestin-primed ovarian stimulation for fertility preservation. J Ovarian Res, 15.
5. Nguyen H.T.T., Ha T.T.T., Tran H.B. và cộng sự. (2023). Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study. Front Nutr, 10, 1251601.
6. Faddy M.J., Gosden R.G., Gougeon A. và cộng sự. (1992). Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod Oxf Engl, 7(10), 1342–1346.
7. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology (2011). The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod Oxf Engl, 26(6), 1270–1283.
8. Nelson S.M., Shaw M., Alrashid K. và cộng sự. (2024). Individualized dosing of follitropin delta affects live birth and safety in in vitro fertilization treatment: an individual participant data meta-analysis of randomized controlled trials. Fertil Steril, 122(3), 445–454.