Article Sidebar

PDF
Date Published: 08/01/2022
Abstract Views: 465
Views PDF: 276
DOI: https://doi.org/10.51298/vmj.v508i2.1651
Issue
Vol. 508 No. 2 (2021)
Section
Các bài báo
How to Cite
Thị Minh Châu, N. ., Việt Hằng, Đào ., & Văn Long, Đào . (2022). EVALUATING SYMPTOM IMPROVEMENT IN PATIENTS WITH ABSENT CONTRACTILITY USING PROTON PUMP INHIBITORS COMBINED WITH PROKINETICS. Vietnam Medical Journal, 508(2). https://doi.org/10.51298/vmj.v508i2.1651

EVALUATING SYMPTOM IMPROVEMENT IN PATIENTS WITH ABSENT CONTRACTILITY USING PROTON PUMP INHIBITORS COMBINED WITH PROKINETICS

Nguyễn Thị Minh Châu1, Đào Việt Hằng1,2,, Đào Văn Long1,2
1 Hanoi Medical University
2 The Institute of Gastroenterology and Hepatology

Main Article Content

Abstract

A longitudinal study was conducted to compare the symptom improvement of patients diagnosed with absent contractility on high-resolution manometry after 1 month using proton pump inhibitors (PPIs) with or without prokinetics. This study included 50 patients between 9/2020 and 6/2021 at Hoang Long Clinic, of which 12 patients received PPI alone, 38 patients received PPI combined withprokinetic treament. The prevalence of female was 58% and the mean age was 48.4 ± 17.7 years. The mean baseline GerdQ score of 2 groups were 5.83 ± 2.79 and 6.68 ± 2.42, the mean baseline FSSG score of 2 groups were10.17 ± 5.34 and 9.55 ± 5.08. There were no differences in GerdQ score and FSSG score before treatmeant between 2 groups. After treatment, there was a significant improvement in GerdQ, FSSG scores in both groups.

Article Details

Keywords

absent contractility, high-resolution manometry, proton pump inhibitors, prokinetics

References

1. Đào Việt Hằng, Lưu Thị Minh Huế, Nguyễn Thùy Linh. Đặc điểm lâm sàng, hình ảnh nội soi và áp lực cơ thắt thực quản dưới ở bệnh nhân có rối loạn mất nhu động thực quản hoàn toàn. Tạp chí nghiên cứu y học trường đại học Y Hà Nội. 2020; 133(9):131-138.
2. FakhreYH, FakhreYaseri AM, Baradaran MA, Soltani A SK. Relationship between esophageal clinical symptoms and manometry findings in patients with esophageal motility disorders: a cross-sectional study. Med J Islam Repub Iran. 2015; 29:271.
3. Farrell B, Pottie K, Thompson W, et al. Deprescribing proton pump inhibitors. Can Fam Physician. 2017;63(5):354-364.
4. Gyawali CP, Sifrim D, Carlson DA, et al. Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium. Neurogastroenterol Motil. 2019; 31(9):13584.
5. Katz PO, Dalton CB, Richter JE, Wu WC, Castell DO. Esophageal testing of patients with noncardiac chest pain or dysphagia. Results of three years’ experience with 1161 patients. Ann Intern Med. 1987; 106(4):593-597.
6. Laique SN, Singh T, Dornblaser D, et al. Clinical Characteristics and Associated Systemic Diseases in Patients With Esophageal “Absent Contractility”—A Clinical Algorithm. Journal of clinical gastroenterology. 2019;53(3):184-190
7. Lin S, Li H, Fang X. Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives. J Neurogastroenterol Motil. 2019;25(4):499-507.
8. Liu L, Li S, Zhu K, et al. Relationship between esophageal motility and severity of gastroesophageal reflux disease according to the Los Angeles classification. Medicine (Baltimore). 2019;98(19):15543.