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Date Published: 08/01/2022
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DOI: https://doi.org/10.51298/vmj.v508i2.1657
Issue
Vol. 508 No. 2 (2021)
Section
Các bài báo
How to Cite
Phát Đạt, B. ., Văn Chương, L. ., Quốc Đạt, N. ., Ngọc Hương, H. ., & Minh Tuấn, H. . (2022). PREVALENCE OF METHICILLIN RESITANCE S. AUREUS AND EFFICACY OF ANTIBIOTIC COMBINATION BETWEEN VANCOMYCIN AND CEFEPIME OR GENTAMICIN AGAINST MRSA ISOLATED FROM BAC LIEU GENERAL HOSPITAL. Vietnam Medical Journal, 508(2). https://doi.org/10.51298/vmj.v508i2.1657

PREVALENCE OF METHICILLIN RESITANCE S. AUREUS AND EFFICACY OF ANTIBIOTIC COMBINATION BETWEEN VANCOMYCIN AND CEFEPIME OR GENTAMICIN AGAINST MRSA ISOLATED FROM BAC LIEU GENERAL HOSPITAL

Bùi Phát Đạt1, Lê Văn Chương2,3, Ngô Quốc Đạt4, Hồ Ngọc Hương1, Huỳnh Minh Tuấn2,5,
1 Bac Lieu Province General Hospital
2 University of Medicine and Pharmacy at Ho Chi Minh City
3 Quality Control Center for Medical Laboratory, University of Medicine and Pharmacy at Ho Chi Minh city
4 University of Medicine and Pharmacy at Ho Chi Minh city
5 University Medical Center Ho Chi Minh City

Main Article Content

Abstract

Background: Methicillin resistant S. aureus (MRSA) is listed by Centers for Disease Control and Prevention as one of the: “Antibiotic Resistance Threats in the United States” because of its severity and multidrug resistance. Antibiotic combination treatment for MRSA infections has been shown promising treatment. Objective: To determine percentages detection of MRSA and efficacy of antibiotic combination between vancomycin and cefepime or gentamicin against MRSA strains. Methods: From 125 strains of S. aureus that were identified and performed routine antibiotic susceptibility testing  by automated machine (Vitek2 Compact), 111 MRSA strains were determined by MIC (minimum inhibitory concentration) cefoxitin screen available in card AST-P592. In vitro antibiotic combination between vancomycin and cefepime on 111 MRSA strains; vancomycin and gentamicin on 53 MRSA strains by microdilution (checkerboard) method. Results: Prevalence of MRSA is 88.8%. MRSA was most widely distributed in pus (61.3%), fluid (22.5%), sputum (10.8%) and blood (5.4%). Based on the FIC (Fractional Inhibitory Concentration) index, vancomycin-cefepime combination showed synergism (45%), additive (51.3%), independent (3.6%) and no antagonism. Vancomycin-gentamicin combination showed synergism (39.6%), additive (58.5%), independent (1.9%) and no antagonism. Conclusion: High rate of MRSA was recorded at Bac Lieu General Hospital. Antibiotic combination between vancomycin and cefepime or gentamicin for high synergistic and additive effect  against MRSA strains. The research results are the basis for doctors to consider the choice of antibiotic combination and the premise to study the effectiveness of antibiotic combination in clinical practice.

Article Details

Keywords

S. aureus, MRSA, combination antibiotics, vancomycin, checkerboard

References

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