CLINICAL CHARACTERISTICS, IMANGING FEATURES, AND FACTORS ASSOCIATED WITH SURGICAL OUTCOMES IN PATIENTS WITH LARGE HEMISPHERIC INFARCTION UNDERGOING DECOMPRESSIVE CRANIECTOMY

Trọng Hiệp Trần, Trung Kiên Trần, Vũ Nguyễn

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Abstract

We conducted a study on 30 patients with large cerebral infarction who underwent decompressive craniectomy between January 2019 and January 2025 at Hanoi Medical University Hospital. The mean age was 59.1 ± 11.2 years, with a male-to-female ratio of 2.75:1. The mean preoperative NIHSS score was 18.4 ± 3.0, and all patients had ASPECTS ≤ 5. On CT imaging, 76.7% of patients presented with a midline shift < 10 mm, while 23.3% had a shift > 10 mm. At hospital discharge, 90% of patients survived and 10% died. At 6-month follow-up (27 patients), 55,6% achieved a favorable functional outcome (mRS 0–3), whereas 44,4% had an unfavorable outcome (mRS 4–6). Decompressive craniectomy in large cerebral infarction proved to be a feasible and safe therapeutic option, with a low postoperative mortality rate.

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References

1. Feigin, Valery L et al. “World Stroke Organization: Global Stroke Fact Sheet 2025.” International journal of stroke: official journal of the International Stroke Society vol. 20,2 (2025): 132-144. doi:10.1177/ 17474930241308142
2. GBD 2021 Forecasting Collaborators. “Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021.” Lancet (London, England) vol. 403,10440 (2024): 2204-2256. doi:10.1016/S0140-6736(24)00685-8
3. Vahedi, Katayoun et al. “Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial).” Stroke vol. 38,9 (2007): 2506-17. doi:10.1161/ STROKEAHA.107.485235
4. Powers, William J et al. “2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/ American Stroke Association.” Stroke vol. 49,3 (2018): e46-e110. doi:10.1161/STR.0000000000000158
5. Chen, Xin et al. “Improvement in Midline Shift Is a Positive Prognostic Predictor for Malignant Middle Cerebral Artery Infarction Patients Undergoing Decompressive Craniectomy.” Frontiers in neurology vol. 12 652827. 20 May. 2021, doi:10.3389/fneur.2021. 652827
6. Gopireddy, P. K. R., R. Sharma, A. Katkar, et al. "Does Age Matter? Unveiling the Impact of Age on Decompressive Craniectomy Outcomes in Malignant Middle Cerebral Artery Infarction: Insights from an Indian Single-Center Study." Egyptian Journal of Neurosurgery, vol. 40, no. 99, 2025, https://doi.org/10.1186/s41984-025-00453-2
7. Goedemans, Taco et al. “Outcome After Decompressive Craniectomy for Middle Cerebral Artery Infarction: Timing of the Intervention.” Neurosurgery vol. 86,3 (2020): E318-E325. doi:10.1093/neuros/nyz522
8. Kim, Dong Wook, et al. “Volumetric Analysis of Malignant Middle Cerebral Infarction (MMI): Infarction Volume Before Decompressive Hemicraniectomy for MMI Is Associated With Poor Consciousness.” Journal of Neurointensive Care, vol. 4, no. 1, 2021, pp. 13–20. Korean Neurointensive Care Society, https://doi.org/10. 32587/jnic.2021.00332