KHẢO SÁT MỐI LIÊN QUAN GIỮA SAF VÀ CÁC CHỈ SỐ ĐÁNH GIÁ CHỨC NĂNG THẬN Ở NGƯỜI VIỆT NAM TRƯỞNG THÀNH KHÔNG ĐÁI THÁO ĐƯỜNG

Abstract

Background: Advanced glycation end-products (AGEs) are compounds that bind to proteins and exhibit fluorescent properties, which can be non-invasively measured as skin autofluorescence (SAF). SAF has been shown to be a biomarker of AGE accumulation in the skin and a better predictor of chronic complications in diabetic patients. Since studies on SAF in non-diabetic adults are still limited, this study was conducted to investigate the relationship between SAF levels and clinical and paraclinical parameters in non-diabetic Vietnamese adults. Methods: A cross-sectional study was conducted on 53 non-diabetic Vietnamese adults visiting the University Medical Center Ho Chi Minh City. SAF values, along with clinical and paraclinical data, were collected. Spearman and Pearson correlation analyses and Student’s t-test were used to assess the associations. Results: SAF levels were significantly higher in participants with hypertension (p<0.05) and those with a history of coronary artery disease (p<0.05) compared to those without these conditions. SAF showed significant positive correlations with age (r = 0.495, p<0.001), HbA1c (r = 0.31, p<0.05), fasting blood glucose (r = 0.36, p<0.01), and serum cystatin C levels (r = 0.44, p<0.01). Significant negative correlations were found between SAF and serum albumin levels (r = -0.39, p<0.01) as well as estimated glomerular filtration rate (eGFR) (r = -0.41, p<0.01). Conclusions: The significant associations between SAF—a marker of AGE accumulation in the skin—and age, HbA1c, fasting glucose, cystatin C, albumin, and eGFR suggest that SAF may serve as an early indicator of metabolic, cardiovascular, and renal risks even in non-diabetic individuals.