SURVEY OF CARDIOVASCULAR RISK IN 10 YEARS ACCORDING TO THE ASCVD SCALE IN GOUT PATIENTS

Lê Phương Thảo Nguyễn, Vĩnh Ngọc Nguyễn, Thị Liễu Lê, thị Vân Hoàng, Thị Mai Quyên Phạm

Main Article Content

Abstract

Objectives: (1) To evaluate the 10-year cardiovascular risk using the ASCVD score in patients with gout. (2) To investigate the association between cardiovascular risk and certain clinical and paraclinical characteristics of the study group.Subjects and Methods: A cross-sectional descriptive study was conducted on 156 patients diagnosed with gout according to the 2015 ACR/EULAR criteria, who attended examination and treatment at Bach Mai Hospital from November 2024 to September 2025. Clinical information (age, sex, disease duration, BMI, gout type, presence of tophi, hypertension, diabetes, smoking) and paraclinical data (uric acid, hs-CRP, blood lipids, glucose) were collected. The 10-year cardiovascular risk was calculated using the ASCVD (Atherosclerotic Cardiovascular Disease Risk Score). Results: The mean age was 56.68 ± 8.94 years, with 66.7% aged ≥ 50 years. The mean disease duration was 4.51 ± 2.91 years; chronic gout accounted for 42.3%, overweight/obesity 56.4%, hypertension 52.6%, dyslipidemia 75.6%, diabetes 13.5%, and smoking 53.2%. The mean ASCVD score was 14.86 ± 10.68%. Risk stratification: low–borderline 35.9%, intermediate 37.8%, high 26.3%. ASCVD risk increased significantly in patients aged ≥ 50 years, disease duration ≥ 5 years, chronic gout, presence of tophi, hypertension, and diabetes, with corresponding values of 15.35; 10.19; 2.94; 13.75; and 3.46 (P < 0.01). Conclusions: Among gout patients, 42.1% had intermediate–high ASCVD cardiovascular risk. Older age, longer disease duration, chronic gout, hypertension, diabetes, smoking, and hyperuricemia contributed to increased risk.

Article Details

References

Choi HK, Curhan G. Independent impact of gout on mortality and risk for coronary heart disease. Circulation. 2007;116(8):894-900. doi:10.1161/ CIRCULATIONAHA.107.703389
2. Zhu Y, Pandya BJ, Choi HK. Comorbidities of Gout and Hyperuricemia in the US General Population: NHANES 2007-2008. Am J Med. 2012;125(7): 679-687.e1. doi:10.1016/j.amjmed. 2011.09.033
3. Goff DC, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk. Circulation. 2014;129 (25_suppl_2): S49-S73. doi:10.1161/01.cir. 0000437741.48606.98
4. Nguyễn Thị Thuỷ. Đặc điểm lâm sàng, cận lâm sàng bệnh gút và một số yếu tố liên quan tại bệnh viện Hữu nghị đa khoa Nghệ An. Tạp chí học việt nam. 2024;544(3).
5. Fraile JM, Torres RJ, de Miguel ME, et al. Metabolic syndrome characteristics in gout patients. Nucleosides Nucleotides Nucleic Acids. 2010; 29(4-6): 325-329. doi:10.1080/ 15257771003738709
6. Juraschek SP, Gelber AC, Choi HK, Appel LJ, Miller ER. Effects of the Dietary Approaches To Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid. Arthritis Rheumatol Hoboken NJ. 2016;68(12):3002-3009. doi:10. 1002/art.39813
7. Nguyễn Thị Phi Nga. Dự báo nguy cơ mắc bệnh mạch vành trong 10 năm tới theo thang điểm Framingham ở bệnh nhân gút tại bệnh viện quân y 103. Học Việt Nam. 2019;478:207-214.
8. McAdams DeMarco MA, Maynard JW, Huizinga MM, et al. Younger age at gout onset is related to obesity in a community-based cohort. Arthritis Care Res. 2011;63(8):1108-1114. doi:10.1002/acr.20479
9. Hồ Thị Ngân Hà. Nghiên cứu các yếu tố nguy cơ của bệnh lý tim mạch ở bệnh nhân gút điều trị tại khoa Cơ xương khớp Bệnh viện Bạch Mai 2014. Y Hà Nội.