XÂY DỰNG MÔ HÌNH PHÂN TÍCH CHI PHÍ – HIỆU QUẢ RUXOLITINIB SO VỚI TRỊ LIỆU TỐT NHẤT HIỆN CÓ TRONG ĐIỀU TRỊ XƠ TỦY NGUYÊN PHÁT TẠI VIỆT NAM

Abstract

Primary myelofibrosis (PMF) is the hematologic disease that had the most unfavorable prognosis in the group of myeloproliferative neoplasms. Ruxolitinib (RUX) had been shown to reduce spleen volume and risk of death compared with the best available therapy (BAT) in PMF treatment.  The choice of the treatment regimen is not only based on effectiveness and safety, but also the cost-effectiveness of interventions, from which the establishment of cost-effectiveness analysis (CEA) model is considered to be one of the most important steps to determine the feasibility and reliability of the analysis. This study combined modeling methods with literature review and clinical expert consultation to build up CEA model of RUX versus BAT in PMF treatment on Microsoft Excel software 2020. The model consists of three parts: input parameters, central model and output parameters. The central model was built based on the Markov model including three states On Treatment, Off treatment and Dead. In which the patient population has equivalent characteristics to the patients in the COMFORT II clinical study with the cycle of 1 month and lifetime horizon. The model helps to analyze the cost-effectiveness of RUX versus BAT in the treatment of PMF and the affecting factors to the cost-effectiveness of RUX.