CLINICAL CHARACTERISTICS AND HEMODYNAMIC PARAMETERS MEASURED BY THORACIC ELECTRICAL BIOIMPEDANCE IN SEPTIC SHOCK PATIENTS UNDERGOING THE PASSIVE LEG RAISING TEST

Văn Hướng Bùi, Ngọc Sơn Đỗ, Thị Hương Giang Bùi, Hữu Thông Trần

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Abstract

Objective: To describe the clinical characteristics and hemodynamic parameters measured by thoracic electrical bioimpedance (TEB) in septic shock patients undergoing the passive leg raising (PLR) test. Subjects and Methods: A cross-sectional descriptive study was conducted on 43 patients diagnosed with septic shock who had an indication for thoracic electrical bioimpedance placement to measure hemodynamic parameters during the passive leg raising test at the Intensive Care Center, Bach Mai Hospital, from August 2024 to August 2025. Results: A total of 43 patients met the inclusion criteria; the majority were male (72.1%), and patients aged ≥ 60 years accounted for a high proportion (62.8%). The most common comorbidities were long-term corticosteroid use (10 patients, 23.3%), hypertension (7 patients, 16.3%), and diabetes mellitus (5 patients, 11.6%). After performing the passive leg raising test, heart rate significantly decreased (104 to 97 beats/min, p < 0.05), stroke volume increased (58 to 63 mL, p < 0.05), and corrected flow time (FTc) increased (305 to 312 ms, p < 0.05). Cardiac output, cardiac index, ICON, cardiac power index, systolic time ratio, and pre-ejection period showed no significant changes. Conclusion: Thoracic electrical bioimpedance allows continuous monitoring and timely detection of hemodynamic changes during the passive leg raising test in patients with septic shock.

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References

Hotchkiss, Richard S., Moldawer, Lyle L., Opal, Steven M., Reinhart, Konrad, Turnbull, Isaiah R., Vincent, Jean-Louis. Sepsis and septic shock. Nat Rev Dis Primer [Internet]. 2016 Jun 30 [cited 2025 Sep 24];2(1):16045. Available from: https://www.nature.com/articles/ nrdp201645
2. Pranskunas A, Gulbinaite E, Navickaite A, Pranskuniene Z. Differences in Hemodynamic Response to Passive Leg Raising Tests during the Day in Healthy Individuals: The Question of Normovolemia. Life [Internet]. 2023 Jul 21 [cited 2025 Sep 25];13(7):1606. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10381249/
3. Li L, Ai Y, Huang L, Ai M, Peng Q, Zhang L. Can bioimpedance cardiography assess hemodynamic response to passive leg raising in critically ill patients. Medicine (Baltimore) [Internet]. 2020 Dec 18 [cited 2025 Sep 29];99(51):e23764. Available from: https://pmc. ncbi.nlm.nih.gov/articles/PMC7748328/
4. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA [Internet]. 2016 Feb 23 [cited 2025 Sep 24];315(8):801–10. Available from: https://pmc. ncbi.nlm.nih.gov/articles/PMC4968574/
5. Søndergaard S. Observational study on passive leg raising and the autonomic nervous system. Physiol Rep [Internet]. 2022 Dec 21 [cited 2025 Sep 25];10(24):e15537. Available from: https:// pmc.ncbi.nlm.nih.gov/articles/PMC9768665/
6. Cholley BP, Singer M. Esophageal Doppler: Noninvasive Cardiac Output Monitor. Echocardiography [Internet]. 2003 [cited 2025 Sep 25];20(8):763–9. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.0742-2822.2003.03033.x
7. van de Water JM, Mount BE, Chandra KMD, Mitchell BP, Woodruff TA, Dalton ML. TFC (thoracic fluid content): a new parameter for assessment of changes in chest fluid volume. Am Surg. 2005 Jan;71(1):81–6.
8. Pham A, Shah NR, Chandran S, Fueta P, O’Daniell E, Burleson J, et al. Assessing Passive Leg Raise Test in Pediatric Shock Using Electrical Cardiometry. J Pediatr Intensive Care [Internet]. 2023 Dec 26 [cited 2025 Sep 27]; Available from: https://www.thieme-connect.de/ products/ejournals/html/10.1055/s-0043-1777798