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IDENTIFICATION OF SNP rs1052133 OF OGG1 GENE IN PATIENTS WITH BREAST CANCER
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Abstract
Background: This study aimed to determine the genotype/allele frequencies of OGG1 Ser326Cys in Vietnamese breast cancer patients and evaluate its association with breast cancer susceptibility. Methods: We conducted a case–control study on 50 female breast cancer patients (primary, untreated) and 50 healthy female controls matched by age. Genomic DNA was extracted from peripheral blood. PCR-RFLP analysis was used to genotype rs1052133, and Sanger sequencing validated the genotyping results. Results: The OGG1 rs1052133 genotype frequencies differed significantly between cases and controls. Among patients, genotype frequencies of CC, CG, GG were 22%, 54%, 24%, compared to 56%, 44%, 0% in controls. The variant G allele (326Cys) was significantly more frequent in patients (51%) than in controls (22%), p < 0.001. This corresponds to an odds ratio of approximately 3.7 for breast cancer associated with the G allele (95% confidence interval 2.0–6.8). Conclusion: Our findings indicate a significant association between the OGG1 Ser326Cys polymorphism and breast cancer risk in the Vietnamese population. The variant 326Cys allele (G) was substantially enriched in patients, suggesting it may confer an increased breast cancer risk.
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References
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