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CLINICAL AND LABORATORY CHARACTERISTICS OF SYSTEMIC LUPUS ERYTHEMATOSUSPATIENTS WITH POSITIVE ANTI-SMITH ANTIBODY
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Abstract
Systemic lupus erythematosus (SLE) is the most common systemic autoimmune disease that predominantly affects women of reproductiveage. The hallmark of SLE is the excessive production of pathogenic antibodies recognizing self-antigens and the formation of antigen-antibody complexes that trigger the immune response to cause multiple organ injuries. Anti-Sm antibodies are directed against seven snRNPs proteins. The specificity of anti-Sm antibodies for classification of SLE reached 90% in a previous study. Objectives: This study describes the clinical and laboratory characteristics of patients with systemic lupus erythematosus with anti-Smithantibody positive. Methods: Cross-sectional descriptive study on 118 patients diagnosed with systemic lupus erythematosus according to SLICC 2012 criteriawho were treated at the center of Allergology and Clinical Immunology, Bach Mai hospital from July 2020 to September 2021. Results: 51.7% of patients had positive anti-Sm antibodies; concentrated mainly in the childbearing age; female/male ratio was 9.7:1; mean age was 31.53 ±11,786 years old. Positive anti-Sm antibodies were associated with decreased complement C4 (p<0.001); not associated with acute skin rash (p=0.057), mucosal ulceration (p=0.103), arthritis (p=0.374), pericardial effusion (p=0.243), pleural effusion (p=0.426), arthritis (p= 0,374), kidney damage at the level of glomerulonephritis or nephrotic syndrome (p=0.579), leukopenia (p=0.582), thrombocytopenia (p=0.347), C3 deficiency (r=0.347; p=0.078) and positive anti-dsDNA double-stranded antibody (p=0.187). (r=0.076; p=0.207). The mean of SLEDAI score in the two groups with or without anti-Sm (13.39± 5.499 and 12.95 ± 6.659, respectively) had no difference with p=0.691. Conclusion: There was an association between anti-Sm antibody positive with decreased complement concentration and Raynaud phenomenon and no correlation between anti-Sm antibody and SLEDAI score and some organ damage in patients with SLE.
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Keywords
Systemic lupus erythematosus, Anti-Smith antibodies, Clinical manifestations, Disease damage, SLEDAI
References
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