NUTRITIONAL STATUS AND PREVALENCE OF REFEEDING SYNDROME IN THE INFECTIOUS DISEASES INTENSIVE CARE UNIT, CHILDREN’S HOSPITAL 1

Quang Huy Trịnh, Nguyễn Thế Nguyên Phùng

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Abstract

Objective: To describe the nutritional status and feeding characteristics; and to determine the prevalence, clinical features, as well as related factors among patients with refeeding syndrome (RFS). Methods: A prospective descriptive case series was conducted on 156 patients aged 2 months to 16 years admitted to the Infectious Disease Intensive Care Unit, Children’s Hospital 1. Results: Among the 156 children, 38,2% had at least one type of undernutrition (acute malnutrition, chronic malnutrition, underweight, or low mid–upper arm circumference), while 14,7% presented with overnutrition (overweight or obesity). In children aged ≤5 years, malnutrition predominated, with rates of acute and chronic malnutrition of 17,1% and 23,1%, respectively. In contrast, among those aged >5 years, overweight and obesity accounted for a substantial proportion (37,5%). Most patients (92,3%) received exclusive enteral nutrition, and 9,0% experienced feeding interruptions, most commonly due to gastrointestinal intolerance (42,9%). Regarding refeeding syndrome, 19,5% of patients were affected. Among them, 50% exhibited concurrent reductions in all three electrolytes (K, Mg, and P), with phosphorus showing the highest rate of severe depletion (57,7%). Two factors found to be associated with refeeding syndrome were age over 24 months and receiving parenteral nutrition. Conclusion: The prevalence of malnutrition among critically ill children remains high. RFS occurs frequently, especially among children over 2 years and those receiving parenteral nutrition

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References

Bùi Quang Vinh, Nguyễn Thị Nguyên, Phùng Nguyễn Thế Nguyên. Tình trạng dinh dưỡng và diễn tiến trên trẻ 1-59 tháng điều trị tại khoa Hồi sức Tích cực - Chống độc bệnh viện Nhi đồng 1 Thành phố Hồ Chí Minh. Tạp chí Dinh dưỡng và Thực phẩm. 2015;13(5):9-14.
2. Nguyễn Thị Thu Hậu, Nguyễn Anh Tuấn, Nguyễn Đỗ Nguyên. Hạ phospho máu và hội chứng nuôi ăn lại. Tạp chí Y học Thành phố Hồ Chí Minh. 2019;23(4):126-35.
3. Doig G. S., Simpson F., Heighes P. T., Bellomo R., Chesher D., Caterson I. D., et al. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respir Med. 2015;3(12):943-52.
4. Mehta N. M., Bechard L. J., Zurakowski D., Duggan C. P., Heyland D. K. Adequate enteral protein intake is inversely associated with 60-d mortality in critically ill children: a multicenter, prospective, cohort study. Am J Clin Nutr. 2015;102(1):199-206.
5. Wong J. J., Ong C., Han W. M., Mehta N. M., Lee J. H. Survey of contemporary feeding practices in critically ill children in the Asia-Pacific and the Middle East. Asia Pac J Clin Nutr. 2016;25(1):118-25.
6. Keehn A., O'Brien C., Mazurak V., Brunet-Wood K., Joffe A., de Caen A., et al. Epidemiology of interruptions to nutrition support in critically ill children in the pediatric intensive care unit. JPEN J Parenter Enteral Nutr. 2015;39(2):211-7.
7. Rungsattatharm L., Kongkiattikul L., Samransamruajkit R., Chomtho S. Achievement of nutritional goals after a pediatric intensive care unit nutrition support guideline implementation. Clin Nutr ESPEN. 2022;50:277-82.
8. Martínez Martínez A, Rodríguez Vignoli A de L, Telechea Ortiz HM. Prevalence of Refeeding Syndrome in a Pediatric Intensive Care Unit. Andes Pediatrica. 2025;96(1):59–66.